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   Articles with "treponema pallidum" as a keyword



Possible effects of Treponema pallidum infection on human vascular endothelial cells

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recommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.24318

Abstract: Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based… read more here.

Keywords: endothelial cells; treponema pallidum; vascular endothelial; pallidum infection ... See more keywords

Relationship between DiaSorin Liaison Treponema pallidum antibody indices and confirmatory assay results in the reverse syphilis testing algorithm.

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recommendations! Published in 2020 at "Diagnostic microbiology and infectious disease"

DOI: 10.1016/j.diagmicrobio.2020.115303

Abstract: Published studies show that >99% of sera reactive in the reverse syphilis testing algorithm (RSTA) screening assay with an index above an assay-specific threshold confirm as reactive, with either a rapid plasma reagin-reactive (RPRR) or… read more here.

Keywords: treponema pallidum; testing algorithm; indices confirmatory; syphilis testing ... See more keywords
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Evaluation of ELISA and CLIA for Treponema pallidum specific antibody detection in China: A multicenter study.

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recommendations! Published in 2019 at "Journal of microbiological methods"

DOI: 10.1016/j.mimet.2019.105742

Abstract: BACKGROUND Considering the rapid increase of syphilis infections in several countries including China, searching for a screening test with sufficient sensitivity and specificity is extremely urgent. The current study mainly researched the performance for Treponema… read more here.

Keywords: treponema pallidum; detection; study; elisa ... See more keywords

ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System.

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recommendations! Published in 2024 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.3c00664

Abstract: The pathogenesis of neurosyphilis remains unclear. A previous study found a noteworthy up-regulation of a disintegrin and metalloproteinase with thrombospondin type 1 motif 5 (ADAMTS5) gene in human brain microvascular endothelial cells cocultured with Treponema… read more here.

Keywords: central nervous; nervous system; invading central; subspecies pallidum ... See more keywords

Design of Epitopes from Treponema pallidum Lipoprotein Antigens for Syphilis Diagnosis and Treatment Prognosis

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recommendations! Published in 2025 at "ACS Infectious Diseases"

DOI: 10.1021/acsinfecdis.5c00155

Abstract: Syphilis, a multistage sexually transmitted infection, causes severe complications if untreated. Accurate diagnosis remains difficult due to the low protein content of Treponema pallidum and in vitro culture difficulty. Advances in immunoproteomics have identified key… read more here.

Keywords: diagnosis; treatment; accuracy; sensitivity ... See more keywords

A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14273

Abstract: Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here… read more here.

Keywords: treponema pallidum; vaccine candidate; syphilis vaccine; vaccine ... See more keywords

405 nm light microbicidal efficacy on Treponema pallidum spiked in ex vivo human platelets

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-03230-1

Abstract: Pathogen reduction technologies using chemicals and or UV light have been demonstrated to improve the safety of ex vivo platelets from infectious diseases. However, UV light exposure also may affect the treated products, depending on… read more here.

Keywords: efficacy treponema; 405 light; light microbicidal; treponema pallidum ... See more keywords

Treponema pallidum outer membrane proteins: current status and prospects.

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recommendations! Published in 2022 at "Pathogens and disease"

DOI: 10.1093/femspd/ftac023

Abstract: The outer membrane proteins (OMPs) of Treponema pallidum subsp. Pallidum (T. pallidum), the etiological agent of the sexually transmitted disease syphilis, has long been a hot research topic. Despite many hurdles to studying the pathogen, especially the inability to manipulate T.… read more here.

Keywords: membrane proteins; pallidum; outer membrane; treponema pallidum ... See more keywords

Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum

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recommendations! Published in 2021 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msab318

Abstract: Abstract The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum… read more here.

Keywords: evolutionary processes; treponema pallidum; pallidum; agent ... See more keywords

Treponema pallidum Strains Among Women and Men Who Have Sex With Women in Amsterdam, the Netherlands and Antwerp, Belgium Between 2014 and 2020

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recommendations! Published in 2023 at "Sexually Transmitted Diseases"

DOI: 10.1097/olq.0000000000001779

Abstract: A different Treponema pallidum strain distribution was found among samples derived from men who have sex with women and women from this study as compared with the same population worldwide. read more here.

Keywords: among women; pallidum strains; sex women; treponema pallidum ... See more keywords

Whole genome sequence of a Treponema pallidum strain from a formalin-fixed paraffin-embedded fine needle aspirate of a cervical lymph node.

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recommendations! Published in 2023 at "Sexually transmitted diseases"

DOI: 10.1097/olq.0000000000001827

Abstract: ABSTRACT A patient with unilateral cervical lymphadenopathy suspicious for malignancy underwent a fine needle aspiration. Histology demonstrated mixed inflammatory infiltrates with abundant spirochetes. Sufficient spirochete DNA was extracted from paraffin-embedded tissue sections to obtain the… read more here.

Keywords: fine needle; treponema pallidum; genome sequence; paraffin embedded ... See more keywords