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   Articles with "trex1" as a keyword



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Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.02.051

Abstract: SUMMARY TREX1 mutations are associated with several auto-immune and inflammatory diseases. The N-terminal DNase domain of TREX1 is important for preventing self-DNA from activating the interferon response. The C terminus of TREX1 is required for… read more here.

Keywords: mitotic phosphorylation; trex1; terminus; phosphorylation trex1 ... See more keywords
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Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation.

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recommendations! Published in 2021 at "Clinical immunology"

DOI: 10.1016/j.clim.2021.108732

Abstract: The 3' repair exonuclease 1 (TREX1) gene encodes a nuclear protein with 3' exonuclease activity, and the mutations have been associated with autoimmune diseases. Herein, we performed genetic analysis for the TREX1 gene in 55… read more here.

Keywords: trex1; systemic lupus; overlapping dermatomyositis; lupus erythematosus ... See more keywords
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The spatial organization of cGAS-TREX1 interactions.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.03.016

Abstract: Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021)… read more here.

Keywords: spatial organization; cgas; trex1; trex1 interactions ... See more keywords
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DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

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recommendations! Published in 2017 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2017.03.001

Abstract: TREX1/DNASE III, the most abundant 3'-5' DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER). Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune and inflammatory conditions such as… read more here.

Keywords: frame shift; dnase; trex1; trex1 frame ... See more keywords

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

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recommendations! Published in 2020 at "Nature genetics"

DOI: 10.1038/s41588-020-0667-5

Abstract: Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes 1 – 5 .… read more here.

Keywords: chromothripsis; chromothripsis kataegis; trex1; telomere crisis ... See more keywords
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TREX1 degrades the 3′ end of the small DNA oligonucleotide products of nucleotide excision repair in human cells

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac214

Abstract: Abstract The nucleotide excision repair (NER) machinery removes UV photoproducts from DNA in the form of small, excised damage-containing DNA oligonucleotides (sedDNAs) ∼30 nt in length. How cells process and degrade these byproducts of DNA… read more here.

Keywords: seddna; nucleotide excision; human cells; excision repair ... See more keywords
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HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products

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recommendations! Published in 2018 at "Journal of Virology"

DOI: 10.1128/jvi.00001-18

Abstract: Much remains unknown about how TREX1 influences HIV-1 replication: whether it targets full-length viral DNA versus partial intermediates, how intracellular TREX1 protein levels correlate with ISG induction, and whether TREX1 digestion of cytoplasmic DNA and… read more here.

Keywords: innate; trex1; dna; level trex1 ... See more keywords
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Abstract 1636: Generation of novel potent human TREX1 inhibitors facilitated by crystallography

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-1636

Abstract: Background: STING is an innate immune sensor critical for the development of immunity. Tumor cells can inactivate the STING pathway to avoid immune recognition, emphasizing its importance in generating tumor-specific immunity. Broad activation of STING… read more here.

Keywords: generation novel; crystallography; trex1 inhibitors; tumor ... See more keywords
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Abstract 5145: Targeting TREX1 induces innate immune response in chemoresistant small cell lung cancer

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5145

Abstract: Small cell lung cancer (SCLC) is the most lethal type of lung cancer. The uniqueness of this tumor consists of an initial exquisite response to chemotherapy. However, at relapse, which occurs nearly in all patients,… read more here.

Keywords: lung cancer; sclc; response; cancer ... See more keywords