DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
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DOI: 10.1016/j.jaut.2017.03.001
Abstract: TREX1/DNASE III, the most abundant 3'-5' DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER). Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune and inflammatory conditions such as… read more here.
Keywords: frame shift; dnase; trex1; trex1 frame ... See more keywords