CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1744-8
Abstract: The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, which… read more here.
Keywords: cdk phosphorylation; phosphorylation trf2; cell cycle; trf2 ... See more keywords
Characterization of t-loop formation by TRF2
Sign Up to like & getrecommendations! Published in 2020 at "Nucleus"
DOI: 10.1080/19491034.2020.1783782
Abstract: ABSTRACT T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ. Here we establish that TRF2 alone, in… read more here.
Keywords: form loops; trf2; loop formation; characterization loop ... See more keywords
The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac065
Abstract: Abstract The shelterin protein complex is required for telomere protection in various eukaryotic organisms. In mammals, the shelterin subunit TRF2 is specialized in preventing ATM activation at telomeres and chromosome end fusion in somatic cells.… read more here.
Keywords: trf2 zebrafish; telomeric evolutionary; trf2; non telomeric ... See more keywords
Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
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DOI: 10.1093/nar/gkx812
Abstract: Abstract Telomeric repeat binding factor 2 (TRF2) folds human telomeres into loops to prevent unwanted DNA repair and chromosome end-joining. The N-terminal basic domain of TRF2 (B-domain) protects the telomeric displacement loop (D-loop) from cleavage… read more here.
Keywords: basic domain; dna; domain trf2; loop ... See more keywords
Functional Comparison of Short and Long Isoforms of the TRF2 Protein in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2019 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672919030165
Abstract: TRF2 protein (TBP-related factor 2) can substitute for TBP forming alternative transcription initiation complexes on TATA-less promoters, including the promoters of histone H1 and piRNA clusters required for transposon repression. The Drosophilatrf2 gene codes for… read more here.
Keywords: short long; trf2; comparison short; trf2 protein ... See more keywords
Inhibition of TRF2 Leads to Ferroptosis, Autophagic Death, and Apoptosis by Causing Telomere Dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/6897268
Abstract: Background Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis. Telomeric repeat-binding factor 2 (TRF2) is a critical telomere protection protein. Emerging evidence indicates that TRF2 may be an… read more here.
Keywords: autophagic death; apoptosis; trf2; dysfunction ... See more keywords