Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.
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DOI: 10.1021/acs.jmedchem.6b01180
Abstract: The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully transferred to our well validated pyridinylimidazole scaffold varying several structural features in order to deduce crucial structure-activity relationships. Joint targeting of the… read more here.
Keywords: pyridinylimidazoles covalent; jun terminal; tri tetrasubstituted; tetrasubstituted pyridinylimidazoles ... See more keywords
Vanadium-Catalyzed Synthesis of Geometrically Defined Acyclic Tri- and Tetrasubstituted Olefins from Propargyl Alcohols
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DOI: 10.1021/acscatal.8b04567
Abstract: A highly selective formation of geometrically defined acyclic tri- and tetrasubstituted alkenes from inexpensive and readily available propargyl alcohols is described. Through vanadium oxo catalysis, tri- and tetrasubstituted α-chloro-, bromo-, and iodo-enone olefins can be… read more here.
Keywords: geometry; defined acyclic; tri tetrasubstituted; acyclic tri ... See more keywords
Mass Efficiency of Alkene Syntheses with Tri- and Tetrasubstituted Double Bonds
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DOI: 10.1021/acssuschemeng.7b02479
Abstract: Environmental factors and process mass intensity were determined and evaluated for more than 30 standard procedures for the synthesis of alkenes with tri- and tetrasubstituted double bonds. They contain some of the most commonly used… read more here.
Keywords: mass efficiency; efficiency alkene; double bonds; tri tetrasubstituted ... See more keywords
Isomerization of N-Allyl Amides To Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00564
Abstract: Enamides represent bioactive pharmacophores in various natural products, and have become increasingly common reagents for asymmetric incorporation of nitrogen functionality. Yet the synthesis of the requisite geometrically defined enamides remains problematic, especially for highly substituted… read more here.
Keywords: amides form; allyl amides; isomerization; tri tetrasubstituted ... See more keywords
Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b01016
Abstract: A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. The electrosynthetic method proceeds through radical cyclization to form the key C-N bond, allowing a variety of hindered… read more here.
Keywords: oxidative amination; intramolecular oxidative; amination; tri tetrasubstituted ... See more keywords
The use of enaminones and enamines as effective synthons for MSA-catalyzed regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles
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DOI: 10.1039/c9nj03701b
Abstract: In the present work, an efficient regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles via a methanesulfonic acid (MSA)-catalyzed reaction of hydrazones with enaminones or enamines is reported. read more here.
Keywords: tetrasubstituted pyrazoles; msa catalyzed; synthesis tri; enaminones enamines ... See more keywords
Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-2009-40
Abstract: A series of novel imidazo[1,2- a ]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2- a ]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p -toluenesulfonic… read more here.
Keywords: containing tri; pyrimidine containing; pyrimidine; tri tetrasubstituted ... See more keywords