Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments
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DOI: 10.1021/acs.jmedchem.5c00301
Abstract: Cyclophilins have been implicated in the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH). Pharmacological inhibition of the cyclophilin B isoform has the potential to attenuate liver fibrosis in MASH, but current cyclophilin inhibitors in clinical trials… read more here.
Keywords: optimization cyclophilin; mash; cyclophilin; tri vector ... See more keywords
SUSY and Tri-Vector Deformations
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DOI: 10.3390/sym14122525
Abstract: We analyze conditions for a tri-vector deformation of a supergravity background to preserve some supersymmetry. Working in the formalism of the SL(5) exceptional field theory, we present its supersymmetry transformations and introduce an additional USp(4)… read more here.
Keywords: tri vector; vector deformations; susy tri;