On the feasibility of pediatric dose-finding trials in small samples with information from a preceding trial in adults.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.2011905
Abstract: We consider the case of pediatric dose-finding trials with extremely limited sample size. The operating characteristics of the standard design, the Continual Reassessment Method (CRM), are only well described for sample sizes of about 20… read more here.
Keywords: pediatric dose; trial; trial adults; feasibility pediatric ... See more keywords