Using cancer registries to supplement clinical trial data and inform regulatory decision
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4931
Abstract: Cancer is a major cause of morbidity and mortality worldwide, particularly in high‐income countries. The burden of disease is immense for patients, their caregivers, and for health care systems. Although treatment options have been expanding… read more here.
Keywords: using cancer; clinical trial; trial data; supplement clinical ... See more keywords
Enhancing the analytic utility of clinical trial data to inform health disparities research
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2020.100677
Abstract: Clinical trials are often conducted among younger, healthier, and less racially diverse patient populations than the population at large. Health disparities for individuals with cancer are most apparent when there are notable differences in the… read more here.
Keywords: trial data; clinical trial; research; cancer ... See more keywords
Predicting tibia shaft nonunions at initial fixation: An external validation of the Nonunion Risk Determination (NURD) score in the SPRINT trial data.
Sign Up to like & getrecommendations! Published in 2020 at "Injury"
DOI: 10.1016/j.injury.2020.06.050
Abstract: BACKGROUND Predictive models are common in orthopedic research; however, most models are not validated in an external population. The Nonunion Risk Determination (NURD) score was developed using a single-center cohort of 382 patients to reliably… read more here.
Keywords: trial data; external validation; sprint; sprint trial ... See more keywords
Estimated legacy effects from simulated post-trial data were less biased than from combined trial/post-trial data.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2019.05.010
Abstract: OBJECTIVES "Legacy effects" describe the phenomena where treatment effects are apparent during the post-trial period that are not attributable to the direct effects observed within the trial. We investigate different approaches to analysis of trial… read more here.
Keywords: post trial; legacy effects; trial; trial data ... See more keywords
Prototype of running clinical trials in an untrustworthy environment using blockchain
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08874-y
Abstract: Monitoring and ensuring the integrity of data within the clinical trial process is currently not always feasible with the current research system. We propose a blockchain-based system to make data collected in the clinical trial process… read more here.
Keywords: clinical trial; trial data; trial; process ... See more keywords
Investigating the veracity of a sample of divergent published trial data in spinal pain.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002659
Abstract: ABSTRACT Evidence-based medicine is replete with studies assessing quality and bias, but few evaluating research integrity or trustworthiness. A recent Cochrane review of psychological interventions for chronic pain identified trials with a shared lead author… read more here.
Keywords: trustworthiness; trial data; pain; risk bias ... See more keywords
From publication bias to lost in information: why we need a central public portal for clinical trial data
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Evidence-Based Medicine"
DOI: 10.1136/bmjebm-2020-111566
Abstract: The availability of clinical trial records has increased markedly. This article outlines the challenges faced in information retrieval for evidence syntheses and provides a proposal for ensuring efficient and complete access to clinical trial records,… read more here.
Keywords: clinical trial; trial data; information; trial ... See more keywords
Mimicking Clinical Trials Using Real-World Data: A Novel Method and Applications
Sign Up to like & getrecommendations! Published in 2022 at "Medical Decision Making"
DOI: 10.1177/0272989x221141381
Abstract: Introduction Simulating individual-level trial data when only summary data are available is often useful for meta-analysis, forming external control arms and calibrating trial results to real-world data (RWD). The joint distribution of baseline characteristics in… read more here.
Keywords: world data; trial data; trial; individual level ... See more keywords
Open Access Platforms in Spinal Cord Injury: Existing Clinical Trial Data to Predict and Improve Outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Neurorehabilitation and Neural Repair"
DOI: 10.1177/1545968316688801
Abstract: Recovery from acute spinal cord injury (SCI) is characterized by extensive heterogeneity, resulting in uncertain prognosis. Reliable prediction of recovery in the acute phase benefits patients and their families directly, as well as improves the… read more here.
Keywords: clinical trial; trial data; cord injury; spinal cord ... See more keywords
Demographic predictors of wellbeing in Carers of people with psychosis: secondary analysis of trial data
Sign Up to like & getrecommendations! Published in 2020 at "BMC Psychiatry"
DOI: 10.1186/s12888-020-02691-0
Abstract: Background Carers of people with psychosis are at a greater risk of physical and mental health problems compared to the general population. Yet, not all carers will experience a decline in health. This predicament has… read more here.
Keywords: people psychosis; trial data; carers people; wellbeing carers ... See more keywords
Discoverability of information on clinical trial data-sharing platforms
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Medical Library Association : JMLA"
DOI: 10.5195/jmla.2021.992
Abstract: Objective: This study was intended to (1) provide clinical trial data-sharing platform designers with insight into users' experiences when attempting to evaluate and access datasets, (2) spark conversations about improving the transparency and discoverability of… read more here.
Keywords: clinical trial; trial data; information; trial ... See more keywords