A practical analysis procedure on generalizing comparative effectiveness in the randomized clinical trial to the real-world trial-eligible population
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2025.2489282
Abstract: ABSTRACT When evaluating the effectiveness of a drug, a randomized controlled trial (RCT) is often considered the gold standard due to its ability to balance effect modifiers through randomization. While RCT assures strong internal validity,… read more here.
Keywords: eligible population; trial; real world; population ... See more keywords
Generalizing causal inferences from individuals in randomized trials to all trial-eligible individuals.
Sign Up to like & getrecommendations! Published in 2018 at "Biometrics"
DOI: 10.1111/biom.13009
Abstract: We consider methods for causal inference in randomized trials nested within cohorts of trial-eligible individuals, including those who are not randomized. We show how baseline covariate data from the entire cohort, and treatment and outcome… read more here.
Keywords: causal inferences; trial; generalizing causal; eligible individuals ... See more keywords
Abstract 121: Prospective Symptomatic Hemorrhage Rates And Functional Outcomes In Trial Eligible Cavernous Angiomas With Symptomatic Hemorrhage
Sign Up to like & getrecommendations! Published in 2023 at "Stroke"
DOI: 10.1161/str.54.suppl_1.121
Abstract: Background: Cerebral cavernous angiomas with symptomatic hemorrhage (CASH) carry highest rebleed rates and are targeted for novel interventions. A multisite clinical trial readiness project (clinicaltrials.gov NCT03652181) aims to identify clinical and functional changes over time… read more here.
Keywords: angiomas symptomatic; hemorrhage; cavernous angiomas; symptomatic hemorrhage ... See more keywords
Identifying Trial-Eligible High- and High-Intermediate Risk Patients with Diffuse Large B-Cell Lymphoma Using Prognostic Models: A Real-Life Comparative Analysis of IPI, aaIPI and NCCN-IPI from Danish Study Group
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DOI: 10.1182/blood-2024-201672
Abstract: Background: The International Prognostic Index (IPI) and age-adjusted IPI (aaIPI) have been used to select patients in recent frontline clinical trials, aiming to challenge R-CHOP as the standard of therapy. As the prognosis following R-CHOP… read more here.
Keywords: risk patients; trial; risk; trial eligible ... See more keywords