Comparison of a Target Trial Emulation Framework vs Cox Regression to Estimate the Association of Corticosteroids With COVID-19 Mortality
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.34425
Abstract: Key Points Question How do modern methods for statistical inference compare with approaches common in the clinical literature when estimating the association of corticosteroids with mortality for patients with moderate to severe COVID-19? Findings In… read more here.
Keywords: mortality; target trial; trial emulation; association corticosteroids ... See more keywords
Stopping mineralocorticoid receptor antagonists after hyperkalemia: trial emulation in data from routine care.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2287
Abstract: AIMS Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalemias, it deprives patients of their cardioprotection. We… read more here.
Keywords: trial emulation; heart failure; mineralocorticoid receptor; hyperkalemia ... See more keywords
Target trial emulation: teaching epidemiology and beyond
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Epidemiology"
DOI: 10.1007/s10654-017-0293-4
Abstract: textabstractObservational epidemiology is continually held to thestandard of randomized trials. A typical epidemiology article references previous trials in the introduction (or reasons why trials are not feasible) and, when possible, compares the results to previous… read more here.
Keywords: target trial; epidemiology; trial; trial emulation ... See more keywords
Target Trial Emulation and Bias Through Missing Eligibility Data: An Application to a Study of Palivizumab for the Prevention of Hospitalization Due to Infant Respiratory Illness
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwac202
Abstract: Abstract Target trial emulation (TTE) applies the principles of randomized controlled trials to the causal analysis of observational data sets. One challenge that is rarely considered in TTE is the sources of bias that may… read more here.
Keywords: eligibility; trial; target trial; eligibility data ... See more keywords
Target Trial Emulation: A Call for More Widespread Use.
Sign Up to like & getrecommendations! Published in 2024 at "American journal of epidemiology"
DOI: 10.1093/aje/kwae222
Abstract: Causal inference methods intended for use with observational data have been widely available for decades, but barriers exist to their widespread adoption. These likely include lack of familiarity with several methodologic techniques often used in… read more here.
Keywords: trial emulation; trial; inference; target trial ... See more keywords
Heterogeneous Cardiovascular Effects of SGLT2 Inhibitors in Type 2 Diabetes: A Causal Forest and Target Trial Emulation Study.
Sign Up to like & getrecommendations! Published in 2025 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwaf539
Abstract: AIMS Evidence is limited as to who benefit the most from sodium-glucose cotransporter-2 inhibitors (SGLT2i), especially among people without elevated cardiovascular disease (CVD) risk. To address this knowledge gap, we investigated the heterogeneity in the… read more here.
Keywords: causal forest; risk; trial emulation; cvd risk ... See more keywords
Target Trial Emulation: Improving the Quality of Observational Studies in Inflammatory Bowel Disease Using the Principles of Randomized Trials
Sign Up to like & getrecommendations! Published in 2024 at "Inflammatory Bowel Diseases"
DOI: 10.1093/ibd/izae131
Abstract: Abstract The past decade has seen a substantial increase in the number of randomized controlled trials (RCTs) conducted in inflammatory bowel disease (IBD). Randomized controlled trials are the gold standard method for generating robust evidence… read more here.
Keywords: trial; trial emulation; observational studies; inflammatory bowel ... See more keywords
Safety outcomes of tocilizumab and tofacitinib treatment for rheumatoid arthritis: Target trial emulation
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.15406
Abstract: Biological disease‐modifying antirheumatic drugs have been the primary treatment option for moderate to severe rheumatoid arthritis (RA) in Taiwan since 2010. Tocilizumab is an interleukin‐6 receptor inhibitor, whereas tofacitinib is a Janus kinase inhibitor. The… read more here.
Keywords: tocilizumab tofacitinib; trial emulation; rheumatoid arthritis; safety outcomes ... See more keywords
Major adverse cardiovascular events (MACE) in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: A target trial emulation study
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-4627
Abstract: Background: Since tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukemia (CML) into a chronic disease with near-normal life expectancy, cardiovascular toxicity has emerged as a leading cause of non-CML mortality. Yet, comparative risk of… read more here.
Keywords: second third; risk; mace; trial emulation ... See more keywords
Evaluating the effectiveness of sociotherapy following psychiatric hospitalization: a target trial emulation protocol using German statutory health insurance data
Sign Up to like & getrecommendations! Published in 2025 at "BMC Health Services Research"
DOI: 10.1186/s12913-025-13137-2
Abstract: The German health care system maintains a strict division between inpatient and outpatient care, posing challenges for the continuity of care. Discharge management facilitates the transition from inpatient to outpatient settings. For psychiatric patients, sociotherapy… read more here.
Keywords: effectiveness sociotherapy; trial; trial emulation; health ... See more keywords
Target Trial Emulation: A Design Tool for Cancer Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "JCO clinical cancer informatics"
DOI: 10.1200/cci.22.00140
Abstract: PURPOSE To apply target trial emulation to explore the potential impact of eligibility criteria on the primary outcome of a randomized controlled trial. METHODS Simulations of a real-world explanatory trial of transarterial radioembolization for advanced… read more here.
Keywords: cancer; target trial; trial emulation; trial ... See more keywords