Comparison of a Target Trial Emulation Framework vs Cox Regression to Estimate the Association of Corticosteroids With COVID-19 Mortality
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.34425
Abstract: Key Points Question How do modern methods for statistical inference compare with approaches common in the clinical literature when estimating the association of corticosteroids with mortality for patients with moderate to severe COVID-19? Findings In… read more here.
Keywords: mortality; target trial; trial emulation; association corticosteroids ... See more keywords
Stopping mineralocorticoid receptor antagonists after hyperkalemia: trial emulation in data from routine care.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2287
Abstract: AIMS Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalemias, it deprives patients of their cardioprotection. We… read more here.
Keywords: trial emulation; heart failure; mineralocorticoid receptor; hyperkalemia ... See more keywords
Target trial emulation: teaching epidemiology and beyond
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Epidemiology"
DOI: 10.1007/s10654-017-0293-4
Abstract: textabstractObservational epidemiology is continually held to thestandard of randomized trials. A typical epidemiology article references previous trials in the introduction (or reasons why trials are not feasible) and, when possible, compares the results to previous… read more here.
Keywords: target trial; epidemiology; trial; trial emulation ... See more keywords
Target Trial Emulation and Bias Through Missing Eligibility Data: An Application to a Study of Palivizumab for the Prevention of Hospitalization Due to Infant Respiratory Illness
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwac202
Abstract: Abstract Target trial emulation (TTE) applies the principles of randomized controlled trials to the causal analysis of observational data sets. One challenge that is rarely considered in TTE is the sources of bias that may… read more here.
Keywords: eligibility; trial; target trial; eligibility data ... See more keywords
Target Trial Emulation: A Design Tool for Cancer Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "JCO clinical cancer informatics"
DOI: 10.1200/cci.22.00140
Abstract: PURPOSE To apply target trial emulation to explore the potential impact of eligibility criteria on the primary outcome of a randomized controlled trial. METHODS Simulations of a real-world explanatory trial of transarterial radioembolization for advanced… read more here.
Keywords: cancer; target trial; trial emulation; trial ... See more keywords
Target Trial Emulation to Improve Causal Inference from Observational Data: What, Why, and How?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000000000152
Abstract: ABSTRACT Target trial emulation has drastically improved the quality of observational studies investigating the effects of interventions. Its ability to prevent avoidable biases that have plagued many observational analyses has contributed to its recent popularity.… read more here.
Keywords: target trial; trial emulation; causal;
Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13030777
Abstract: Methodological biases are common in observational studies evaluating treatment effectiveness. The objective of this study is to emulate a target trial in a competing risks setting using hospital-based observational data. We extend established methodology accounting… read more here.
Keywords: target trial; trial emulation; trial; using hospital ... See more keywords