PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors
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DOI: 10.1111/hae.14418
Abstract: Surgical procedures in persons with haemophilia A or B with inhibitors (PwHABI) require the use of bypassing agents (BPA) and carry a high risk of complications. Historically, only two BPAs have been available; these are… read more here.
Keywords: clinical trial; trial evaluate; haemophilia inhibitors; persept phase ... See more keywords
A Multicenter Randomized Controlled Trial To Evaluate the Efficacy and Safety of Nelfinavir in Patients with Mild COVID-19
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DOI: 10.1128/spectrum.04311-22
Abstract: The anti-HIV drug nelfinavir suppresses the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro. However, its efficacy in patients with COVID-19 has not been studied. ABSTRACT Nelfinavir, an orally administered inhibitor of… read more here.
Keywords: randomized controlled; efficacy; group; controlled trial ... See more keywords
A preclinical trial to evaluate therapies for BRCA-associated pancreatic cancer.
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DOI: 10.1200/jco.2017.35.4_suppl.332
Abstract: 332Background: Pancreatic ductal adenocarcinoma (PDAC) associated with germline BRCA1 or BRCA2mutations may have selective sensitivity to agents that exploit homologous recombination DNA repair defects. We hypothesized that cisplatin, a DNA-crosslinking agent, and talazoparib, a poly(ADP-ribose)… read more here.
Keywords: trial; trial evaluate; cisplatin; brca associated ... See more keywords
CONFIRM: A phase III randomized trial to evaluate the efficacy of nivolumab versus placebo in relapsed mesothelioma.
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DOI: 10.1200/jco.2018.36.15_suppl.tps8586
Abstract: TPS8586Background: Mesothelioma, an incurable, apoptosis-resistant cancer, represents a growing health burden but remains under-researched, with limited treatment options. Despite a significant num... read more here.
Keywords: mesothelioma; trial evaluate; iii randomized; phase iii ... See more keywords
Corrigendum: Basis and Design of a Randomized Clinical Trial to Evaluate the Effect of Jinlida Granules on Metabolic Syndrome in Patients With Abnormal Glucose Metabolism
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DOI: 10.3389/fendo.2020.00649
Abstract: [This corrects the article DOI: 10.3389/fendo.2020.00415.]. read more here.
Keywords: corrigendum basis; clinical trial; design randomized; trial evaluate ... See more keywords