Randomized Controlled Trial Evaluating Levetiracetam as First-line Therapy for Seizures in Neonates
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DOI: 10.1007/s13312-020-1965-9
Abstract: This multicenter, randomized, blinded, controlled, trial investigated the efficacy and safety of levetiracetam compared with phenobarbital as a preferred treatment for neonatal seizures of any cause. The primary outcome variable was complete seizure freedom for… read more here.
Keywords: randomized controlled; randomly assigned; levetiracetam; controlled trial ... See more keywords
Traumatic injury clinical trial evaluating tranexamic acid in children (TIC‐TOC): A pilot randomized trial
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DOI: 10.1111/acem.14481
Abstract: The antifibrinolytic drug tranexamic acid (TXA) improves survival in adults with traumatic hemorrhage; however, the drug has not been evaluated in a trial in injured children. We assessed the feasibility of a large‐scale trial evaluating… read more here.
Keywords: trial evaluating; traumatic injury; trial; clinical trial ... See more keywords
Effect of race on the glycaemic response to sitagliptin: Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)
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DOI: 10.1111/dom.13242
Abstract: Pooled efficacy studies suggest that glycaemic responses to dipeptidyl‐peptidase 4 inhibitors in type 2 diabetes are greatest in Asians, who may also respond better to alpha‐glucosidase inhibitors. We assessed the glycaemic impact of sitagliptin by… read more here.
Keywords: evaluating cardiovascular; sitagliptin tecos; cardiovascular outcomes; outcomes sitagliptin ... See more keywords
A prospective multicenter clinical trial evaluating the efficacy and safety of a hyaluronic acid‐based filler with Tri‐Hyal technology in the treatment of lips and the perioral area
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DOI: 10.1111/jocd.15169
Abstract: Age‐related changes of facial soft tissue cause clinical signs of facial aging such as lip atrophy, marionette lines, and an accentuated nasolabial fold. These changes can be modified using dermal fillers. read more here.
Keywords: multicenter clinical; trial evaluating; evaluating efficacy; efficacy safety ... See more keywords
Results of a phase Ib trial evaluating the safety and clinical activity of sapanisertib (TAK 228) in combination with serabelisib (TAK 117) and paclitaxel in patients with advanced ovarian, endometrial, or breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.3604
Abstract: 3604Background: The link between taxane resistance and activation of PI3K/AKT/mTOR signaling suggests that by inhibiting this pathway in combination with anti-microtubule agents like paclitaxel may... read more here.
Keywords: combination; results phase; paclitaxel; evaluating safety ... See more keywords
Assessing the Safety of Sitagliptin in Older Participants in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)
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DOI: 10.2337/dc16-1135
Abstract: OBJECTIVE Limited data exist regarding safety and efficacy of antihyperglycemic drugs in older patients with type 2 diabetes. The Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) was a randomized, double-blind, placebo-controlled trial assessing the impact… read more here.
Keywords: evaluating cardiovascular; trial; sitagliptin; safety ... See more keywords