Optimizing and evaluating biomarker combinations as trial-level general surrogates.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.7996
Abstract: We extend the method proposed in a recent work by the Authors for trial-level general surrogate evaluation to allow combinations of biomarkers and provide a procedure for finding the "best" combination of biomarkers based on… read more here.
Keywords: level general; biomarker; trial level; general surrogates ... See more keywords
The stability and reliability of attentional bias measures in the dot-probe task: Evidence from both traditional mean bias scores and trial-level bias scores
Sign Up to like & getrecommendations! Published in 2020 at "Motivation and Emotion"
DOI: 10.1007/s11031-020-09834-6
Abstract: A new method of calculating attentional bias from the dot-probe task measures fluctuations in bias towards and away from emotional stimuli over time using trial level bias score metrics. We assessed the stability and reliability… read more here.
Keywords: attentional bias; bias; trial level; level bias ... See more keywords
663 Correlation between early endpoints and overall survival in non-small-cell lung cancer: a trial-level meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0663
Abstract: Background In clinical trials that assess novel therapeutic agents in patients with non-small-cell lung cancer (NSCLC), early endpoints (e.g. progression-free survival [PFS] and objective response rate) are often evaluated as indicators of biological drug activity,… read more here.
Keywords: trial; early endpoints; non small; cancer ... See more keywords
Correlation Between Early Endpoints and Overall Survival in Non-Small-Cell Lung Cancer: A Trial-Level Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.672916
Abstract: Early endpoints, such as progression-free survival (PFS), are increasingly used as surrogates for overall survival (OS) to accelerate approval of novel oncology agents. Compiling trial-level data from randomized controlled trials (RCTs) could help to develop… read more here.
Keywords: trial; early endpoints; level; oncology ... See more keywords