Trial registration in pediatric surgery trials.
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DOI: 10.1016/j.jpedsurg.2017.10.049
Abstract: BACKGROUND Prospective clinical trial registration serves to increase transparency and to mitigate selective reporting bias. An assessment of adult surgical trials revealed poor trial registration practice with incomplete provision of information in registries and inconsistent… read more here.
Keywords: trial; trial registration; pediatric surgery; surgery trials ... See more keywords
A patent review of BRAF inhibitors: 2013-2018
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DOI: 10.1080/13543776.2019.1640680
Abstract: ABSTRACT Introduction: As a key element in arguably the most important pathway MAPK signaling, the BRAF kinase gives rise to severe diseases including cancers when pathologically activated. Extensive research on BRAFi (BRAF inhibitor) has been… read more here.
Keywords: brafi; trial registration; registration clinicaltrials; braf ... See more keywords
The NK1 receptor antagonist serlopitant for treatment of chronic pruritus
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DOI: 10.1080/13543784.2019.1638910
Abstract: ABSTRACT Introduction: Pruritus is a common symptom associated with several potential underlying causes, including both dermatologic and systemic diseases; it can also occur without an identifiable cause. Current treatment options are limited and most patients… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords
Investigational drugs in early-stage clinical trials for autism spectrum disorder
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DOI: 10.1080/13543784.2019.1649656
Abstract: ABSTRACT Introduction: Pharmacologic interventions in Autism Spectrum Disorder (ASD) have historically focused on symptom-based approaches. However, a treatment for the core social deficits has remained unidentified. While a definitive theory for the cause of ASD… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords
Current and emerging biologics for the treatment of hereditary angioedema
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DOI: 10.1080/14712598.2019.1595581
Abstract: ABSTRACT Introduction: Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) is a rare disease with unpredictable, self-limiting and localized swelling episodes involving the cutaneous and subcutaneous tissues. In the last decade, the spectrum of the possibilities… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords
Monoclonal antibodies: new chance in the management of B-cell acute lymphoblastic leukemia
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DOI: 10.1080/16078454.2022.2074704
Abstract: ABSTRACT Objectives This review aims to see the progress of several clinically-used monoclonal antibodies in treating ALL patients and how they improved patients' outcomes. Methods We searched Web of Science, Elsevier and PubMed for relevant… read more here.
Keywords: gov identifier; clinicaltrials gov; registration clinicaltrials; trial registration ... See more keywords
Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability
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DOI: 10.1080/17425247.2019.1567490
Abstract: ABSTRACT Introduction: Treatment of several diseases of the brain are complicated by the presence of the skull and the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubble (MB)-mediated BBB treatment is a minimally invasive method… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords
Journal response: prospective clinical trial registration – desirable, but not necessary
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DOI: 10.1111/anae.14198
Abstract: In this edition of Anaesthesia, we have published an articulate editorial by Smith and Dworkin [1]. They argue strongly in favour of mandatory prospective trial registration, enforced by journals, and they present a robust case… read more here.
Keywords: trial; ethical review; trial registration; journal ... See more keywords
A review of prospective trial registration in the Journal of Advanced Nursing in 2018.
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DOI: 10.1111/jan.14090
Abstract: Registration creates a public record of planned clinical trials and is perhaps that most important weapon in ensuring unbiased reporting of clinical research. It is argued that registration reduces publication bias, the phenomenon where more… read more here.
Keywords: trial registration; journal advanced; prospective trial; registration ... See more keywords
Trial registration and adherence to reporting guidelines in cardiovascular journals
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DOI: 10.1136/heartjnl-2017-312165
Abstract: Objective This study investigated the policies of cardiac and cardiovascular system journals concerning clinical trial registration and guideline adoption to understand how frequently journals use these mechanisms to improve transparency, trial reporting and overall study… read more here.
Keywords: trial; trial registration; registration; registration adherence ... See more keywords
Heartbeat: Reporting guidelines for high quality clinical cardiology research
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DOI: 10.1136/heartjnl-2018-313339
Abstract: Publication in a reputable journal is an essential step in clinical cardiovascular research. Publication allows both dissemination and archiving of research results, including details of methodology, so that other researchers and the general public can… read more here.
Keywords: cardiology; trial registration; quality; research ... See more keywords