Interpreting clinical trial results by deductive reasoning: In search of improved trial design
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700103
Abstract: Clinical trial results are often interpreted by inductive reasoning, in a trial design-limited manner, directed toward modifications of the current clinical practice. Deductive reasoning is an alternative in which results of relevant trials are combined… read more here.
Keywords: clinical trial; deductive reasoning; trial; trial results ... See more keywords
Reporting Clinical Trial Results of Phytomedicines in Acute Rhinosinusitis: Letter to the Editor Regarding Gottschlich S, Röschmann K, Candler H. Adv Ther (2018); 35:1023–1034. doi: 10.1007/s12325-018-0736-7
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Therapy"
DOI: 10.1007/s12325-019-00933-6
Abstract: In their recent article in Advances in Therapy, Gottschlich et al. [1] concluded that the phytomedicines ELOM-080 and BNO 1016 were well tolerated and were of comparable effectiveness in treating acute rhinosinusitis (ARS). We noted… read more here.
Keywords: acute rhinosinusitis; clinical trial; trial; article ... See more keywords
The fragility of trial results involves more than statistical significance alone.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.02.011
Abstract: OBJECTIVES The fragility of clinical trial findings has been previously defined as the number of changes in outcomes that are required to change their statistical significance. We show that reliance on statistical significance alone provides… read more here.
Keywords: statistical significance; clinical importance; trial results; significance alone ... See more keywords
Rapid, accurate publication and dissemination of clinical trial results: benefits and challenges.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad279
Abstract: Large-scale clinical trials are essential in cardiology and require rapid, accurate publication, and dissemination. Whereas conference presentations, press releases, and social media disseminate information quickly and often receive considerable coverage by mainstream and healthcare media,… read more here.
Keywords: rapid accurate; trial results; accurate publication; dissemination ... See more keywords
Profound reductions in first and total cardiovascular events with icosapent ethyl in the REDUCE-IT trial: why these results usher in a new era in dyslipidaemia therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz778
Abstract: Abstract The aims of this clinical review are to: (i) highlight the importance of elevated baseline triglycerides (TG) in the setting of well-controlled low-density lipoprotein cholesterol (LDL-C) on statins as a major contributor to residual… read more here.
Keywords: trial; events icosapent; trial results; profound reductions ... See more keywords
Simulation and Field Trial Results of Reconfigurable Intelligent Surfaces in 5G Networks
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Access"
DOI: 10.1109/access.2022.3223447
Abstract: Recently, reconfigurable intelligent surfaces (RISs) are considered as a strong candidate for next generation wireless technologies, thanks to its advantage of being able to configure the wireless propagation environment in a cost-effective and energy-efficient way.… read more here.
Keywords: trial results; simulation field; reconfigurable intelligent; field ... See more keywords
Phase 3 clinical trial results for nirsevimab: Is it time to consider population‐level RSV immunoprophylaxis?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Paediatrics and Child Health"
DOI: 10.1111/jpc.15999
Abstract: Cytomegalovirus (CMV), a ubiquitous betaherpesvirus, is a common cause of long-term morbidity in neonates. Congenital CMV (cCMV) is the leading cause of acquired sensorineural hearing loss. Post-natal acquisition of CMV (pCMV) is also common, severe… read more here.
Keywords: trial results; results nirsevimab; cmv; clinical trial ... See more keywords
Providing trial results to participants in phase III pragmatic effectiveness RCTs: a scoping review
Sign Up to like & getrecommendations! Published in 2021 at "Trials"
DOI: 10.1186/s13063-021-05300-x
Abstract: Background There is an ethical imperative to offer the results of trials to those who participated. Existing research highlights that less than a third of trials do so, despite the desire of participants to receive… read more here.
Keywords: results participants; scoping review; trial; trial results ... See more keywords
Reflections on translation: Views of participants in a multisite Canadian CCSVI clinical trial
Sign Up to like & getrecommendations! Published in 2018 at "Neurology: Clinical Practice"
DOI: 10.1212/cpj.0000000000000462
Abstract: Background We sought to characterize the perspectives of participants in Canada's phase I/II chronic cerebrospinal venous insufficiency (CCSVI) clinical trial prior to and after the disclosure of trial results. Methods This was a researcher-administered survey… read more here.
Keywords: clinical trial; trial; mean score; trial results ... See more keywords