A randomized trial of safety, pharmacokinetics and pharmacodynamics of concizumab in people with hemophilia A
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14272
Abstract: Essentials explorer™3 was a double‐blinded, multiple‐dose escalation trial of subcutaneous concizumab. A pharmacodynamic relationship for unbound TFPI and thrombin generation was confirmed. No serious adverse events and no anti‐drug antibodies were observed. explorer™3 data support… read more here.
Keywords: trial safety; concizumab people; randomized trial; safety pharmacokinetics ... See more keywords
A clinical trial for the safety and immunogenicity of a DNA-based immunotherapy in men with biochemically (PSA) relapsed prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.80
Abstract: 80Background: Introducing amino acid sequence changes in highly expressed self-antigens for androgen sensitive prostate cancer pts might be sufficient to break tolerance, thus a DNA vaccine was developed using SynCon PSA and PSMA (INO-5150) that… read more here.
Keywords: clinical trial; trial safety; prostate cancer; cancer ... See more keywords