Most noninferiority trials were not designed to preserve active comparator treatment effects.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2019.03.003
Abstract: OBJECTIVES To evaluate whether noninferiority trials are designed to adequately preserve the historical treatment effect of their active comparators. STUDY DESIGN AND SETTING We reviewed 162 noninferiority trials published in high-impact medical journals. We assessed… read more here.
Keywords: active comparator; treatment; trials designed; noninferiority trials ... See more keywords