Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2018.02.013
Abstract: OBJECTIVES Clinical trials in neurodegenerative disorders are facing high futility rates and rising development costs. We aim to review and exemplify the value of group sequential trial designs (i.e., designs with one or more prospectively… read more here.
Keywords: trials neurodegenerative; trial; neurodegenerative disorders; group sequential ... See more keywords
Value-Generating Exploratory Trials in Neurodegenerative Dementias
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011774
Abstract: Drug development for Alzheimer disease and other neurodegenerative dementias, including frontotemporal dementia, has experienced a long history of phase 2 and phase 3 clinical trials that failed to show efficacy of investigational drugs. Despite differences… read more here.
Keywords: development; trials neurodegenerative; exploratory trials; value generating ... See more keywords