Evolution of early phase clinical trials in oncology
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DOI: 10.1007/s00109-017-1612-7
Abstract: The therapeutic armamentarium for the treatment of cancer has rapidly evolved with the advent of molecularly targeted and immuno-oncology agents. Dramatic and prolonged responses observed in patients with advanced cancers have created excitement and promise… read more here.
Keywords: trials oncology; early phase; clinical trials; oncology ... See more keywords
New designs for basket clinical trials in oncology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1372779
Abstract: ABSTRACT The established molecular heterogeneity of human cancers has had profound effects on the design of cancer therapeutics. Most cancer drugs are today targeted to molecular alterations present in cancer cells. Tumors of the same… read more here.
Keywords: designs basket; basket clinical; trials oncology; clinical trials ... See more keywords
Common misconceptions of randomized controlled trials in oncology
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DOI: 10.1111/eci.13832
Abstract: In biomedicine, randomized controlled trials are regarded as the gold standard of evidence owing to their ability to minimize confounding factors that may influence results. Randomized trials that are properly designed serve as a basis… read more here.
Keywords: oncology; misconceptions randomized; randomized controlled; controlled trials ... See more keywords
Phase I clinical trials in oncology: A review of the old and a look at the new.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14030
Abstract: e14030Background: In Phase I oncology trials the primary goal is to assess dose limiting toxicities (DLT) and estimate the maximum tolerated dose (MTD). The classical 3+3 design is still used in greater than 90% of… read more here.
Keywords: phase; trials oncology; clinical trials; oncology ... See more keywords