Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2016.10.018
Abstract: Insights into the pathogenesis of inflammatory bowel diseases (IBDs) have provided important information for the development of therapeutics. Levels of interleukin 23 (IL23) and T-helper (Th) 17 cell pathway molecules are increased in inflamed intestinal… read more here.
Keywords: inflammatory bowel; trials targeting; bowel diseases; lessons learned ... See more keywords
Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202208-1579ed
Abstract: exposure to increased or decreased ambient temperature. Sci Total Environ 2021;772:145383. 9. Willson BE, Gee NA, Willits NH, Li L, Zhang Q, Pinkerton KE, et al. Effects of the 2018 camp fire on birth outcomes… read more here.
Keywords: three trials; trials clinical; clinical trials; targeting integrin ... See more keywords
The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson’s Disease
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DOI: 10.3233/jpd-191648
Abstract: As therapeutic trials target early stages of Parkinson’s disease (PD), appropriate patient selection based purely on clinical criteria poses significant challenges. Members of the Critical Path for Parkinson’s Consortium formally submitted documentation to the European… read more here.
Keywords: stages parkinson; early stages; biomarker; parkinson disease ... See more keywords