Triarylaminium Radical Cation Promoted Coupling of Catharanthine with Vindoline: Diastereospecific Synthesis of Anhydrovinblastine and Reaction Scope.
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DOI: 10.1021/jacs.9b06968
Abstract: A new triarylaminium radical cation promoted coupling of catharanthine with vindoline is disclosed, enlisting tris(4-bromophenyl)aminium hexachlororantimonate (BAHA, 1.1 equiv) in aqueous 0.05 N HCl/trifluoroethanol (2-10:1) at room temperature (25 °C), that provides anhydrovinblastine in superb… read more here.
Keywords: triarylaminium radical; catharanthine vindoline; radical cation; reaction ... See more keywords