Design and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.063
Abstract: s-Triazine is considered a privileged structure, as it is found in several FDA-approved drugs. In the framework of our ongoing medicinal chemistry project based on the use of s-triazine as a scaffold, we synthesized a… read more here.
Keywords: pyrazolyl triazine; chemistry; cancer; triazine derivatives ... See more keywords
Optoelectronic properties of the newly designed 1,3,5-triazine derivatives with isatin, chalcone and acridone moieties
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2021.113160
Abstract: Abstract We have proposed the structures of three 1,3,5-triazine-2,4-diamine analogs and subjected them to density functional theory (DFT) calculations and molecular dynamics (MD) simulations to assess their potential for applications in the area of organic… read more here.
Keywords: newly designed; properties newly; acridone moieties; triazine derivatives ... See more keywords
Interfacial Film Conformation and Its Molecular Arrangement of s-Triazine Derivatives Containing Three Fluorocarbons without Hydrophilic Groups
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2021.109880
Abstract: ABSTRACT A monolayer on the water surface or a Langmuir monolayer of fluorinated long-chain s-triazine derivatives with no hydrophilic groups was formed, and its interfacial conformation was verified. As a highly water-repellent monolayer-forming substance, s-triazine… read more here.
Keywords: water surface; water; monolayer; hydrophilic groups ... See more keywords
Novel pyrazolyl-s-triazine derivatives, molecular structure and antimicrobial activity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.05.040
Abstract: Abstract A new series of pyrazole-containing s-triazine derivatives were synthesized by reaction of the corresponding s-triazinyl hydrazine derivatives with acetylacetone in the presence of HClO 4 or DMF/TEA. The former method allowed the preparation of… read more here.
Keywords: pyrazolyl triazine; molecular structure; novel pyrazolyl; triazine derivatives ... See more keywords
Tribological properties and tribochemistry mechanism of sulfur-containing triazine derivatives in water-glycol
Sign Up to like & getrecommendations! Published in 2017 at "Tribology International"
DOI: 10.1016/j.triboint.2016.12.038
Abstract: Two triazine derivatives, 6-(diethanolamino)−2,4-bi-(sodium sulfanilate-yl)−1,3,5-triazine (STB) and 6-(ethyl xanthate)−2,4-bi-(sodium sulfanilate-yl)−1,3,5-triazine (STC) were synthesized and used as additives in water-glycol base fluid (mass ratio 1:1). Water solubility tests indicated that STB and STC met the solubility… read more here.
Keywords: water glycol; sulfur; water; stb stc ... See more keywords
Electronic and Optical Properties of Protonated Triazine Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.0c08812
Abstract: The peculiar electronic and optical properties of covalent organic frameworks (COFs) are largely determined by protonation, a ubiquitous phenomenon in the solution environment in which they are synthesized. The resulting effects are non-trivial and appear… read more here.
Keywords: protonated triazine; properties protonated; optical properties; electronic optical ... See more keywords
Copper(II)-Catalyzed C-H Nitrogenation/Annulation Cascade of Ketene N,S-Acetals with Aryldiazonium Salts: A Direct Access to N2-Substituted Triazole and Triazine Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04335
Abstract: Direct synthesis of N2-substituted triazole and triazine derivatives has been a challenge in N-heterocyclic chemistry. Under copper(II) catalysis ketene N,S-acetals, that is, alkylthio-substituted enaminones, efficiently reacted with aryldiazonium salts to allow the regioselective generation of… read more here.
Keywords: aryldiazonium salts; triazole triazine; substituted triazole; triazine derivatives ... See more keywords
Vesicles Constructed with Chiral Amphiphilic Oxacalix[2]arene[2]triazine Derivatives for Enantioselective Recognition of Organic Anions.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b18723
Abstract: Chiral amphiphilic oxacalix[2]arene[2]triazine derivatives 1-3 bearing l-prolinol moieties were synthesized. The self-assembly behavior of the chiral macrocyclic amphiphiles was investigated. SEM, TEM, and DLS measurements demonstrated that 1 formed stable vesicles (size of ∼90 nm),… read more here.
Keywords: amphiphilic oxacalix; chiral amphiphilic; arene triazine; triazine derivatives ... See more keywords
1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00122
Abstract: Provided herein are 1,2,4-triazine derivatives used as NLRP3 inhibitors, their pharmaceutical compositions, the use of such compounds in treating diseases and processes for preparing such compounds. read more here.
Keywords: treating diseases; chemistry; derivatives nlrp3; inhibitors treating ... See more keywords
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03079
Abstract: Here, we synthesized a newseries of mono- and bis(dimethylpyrazolyl)-s-triazine derivatives. The synthetic methodology involved the reaction of different mono- and dihydrazinyl-s-triazine derivatives with acetylacetone in the presence of triethylamine to produce the corresponding target products… read more here.
Keywords: dimethylpyrazolyl triazine; bis dimethylpyrazolyl; triazine; activity ... See more keywords
Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01273
Abstract: The biological benefits of trisubstituted 1,3,5-triazine derivatives include their ability to reduce inflammation and fight cancer. A unique series of sulfonamide–triazine hybrid molecules were produced chemically by synthesizing triazine derivatives utilizing the usual nucleophilic aromatic… read more here.
Keywords: triazine hybrid; evaluation anticancer; triazine derivatives; sulfonamide triazine ... See more keywords