Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00074
Abstract: A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced intracellular survival (Eis) protein. Eis is an acetyltransferase that multiacetylates KAN and other aminoglycosides, rendering them unable to bind the… read more here.
Keywords: eis; triazino indole; tuberculosis; resistance ... See more keywords
Synthesis and antimicrobial activity of novel fused [1,2,4]triazino[5,6-b]indole derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217060202
Abstract: Synthesis of new fused systems of triazino[5,6-b]indole starting with preparation of 3-amino[1,2,4]-triazino[5,6-b]indole 1 by reaction of isatin with 2-aminoguanidinium carbonate in boiling acetic acid is presented [1]. Intermediate compound 1 reacted with aldehyde, ethyl chloroformate,… read more here.
Keywords: triazino indol; triazino; antimicrobial activity; triazino indole ... See more keywords