Articles with "triazol trifluoromethoxy" as a keyword



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VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.

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Published in 2017 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.7b00429

Abstract: Herein, we report the structure-activity relationships within a series of mGlu7 NAMs based on an N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4). Analogues in this series displayed steep SAR. Of these,… read more here.

Keywords: vu6010608 novel; trifluoromethoxy phenyl; mglu7; triazol trifluoromethoxy ... See more keywords