Acute toxicity and antitumor potential of 1,3,4‐trisubstituted‐1,2,3‐triazole dhmtAc‐loaded liposomes on a triple‐negative breast cancer model
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200004
Abstract: For the first time, compounds developed from the 1,2,3‐triazole scaffold were evaluated as novel drugs to treat triple‐negative breast cancer (TNBC). Four organic salts were idealized as nonclassical bioisosteres of miltefosine, which is used in… read more here.
Keywords: triple negative; toxicity; triazole; dhmtac ... See more keywords
1H-1,2,3-Triazole: From Structure to Function and Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2770
Abstract: The heterocyclic family of azoles have recently become one of the most widely used members of the N-heterocycles; the most prominent one being 1H-1,2,3-triazole and its derivatives. The sudden growth of interest in this structural… read more here.
Keywords: click chemistry; triazole; triazole structure; chemistry ... See more keywords
Microwave-assisted-demulsification dispersive liquid-liquid microextraction for the determination of triazole fungicides in water by gas chromatography with mass spectrometry.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201800860
Abstract: A novel microwave-assisted-demulsification dispersive liquid-liquid microextraction technique was established for determination of three triazole fungicides in environmental water samples by gas chromatography with mass spectrometry. Importantly, microwave irradiation has been applied in demulsification to achieve… read more here.
Keywords: liquid; triazole; demulsification; water ... See more keywords
1,2,3,-Triazole-Based Catalysts: From Metal- to Supramolecular Organic Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical record"
DOI: 10.1002/tcr.201600104
Abstract: 1,2,3-Triazoles are unique heterocycles with intriguing physical properties that allow not only the coordination to metals, but also the establishment of supramolecular interactions based on their polarized C-H bonds. In this account, an extensive work… read more here.
Keywords: metal supramolecular; triazole; catalysis; catalysts metal ... See more keywords
Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.028
Abstract: Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring closure generated novel 6-alkylfuro[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids (24b-37b),… read more here.
Keywords: triazole; pyrimidine one; chemistry; pyrimidine ... See more keywords
Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.057
Abstract: In this study, forty-four chiral triazole derivatives have been prepared via asymmetric synthesis, and which has been successfully characterized by typical spectroscopic techniques including 1H NMR, 13C NMR, EI-MS, elemental analysis and optical rotations. Their… read more here.
Keywords: triazole; triazole derivatives; vitro antiviral; asymmetric synthesis ... See more keywords
Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.020
Abstract: Currently, the available antifungal agents have significant clinical incompetency in terms of their clinical efficacy, antifungal spectrum, unfavorable pharmacokinetic profiles, substantial side effects and drug-drug interactions. Thus, the optimization and improvement of existing drugs and… read more here.
Keywords: alcohols derived; triazole; design; silico studies ... See more keywords
Cooperative spin transition in a 1D-polymeric complex [Fe(4-ethyl-1,2,4-triazole)3]SiF6·nH2O
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119560
Abstract: Abstract A new 1D-polymeric iron(II)-1,2,4-triazole complex, [Fe(EtTrz)3]SiF6·nH2O (EtTrz = 4-ethyl-1,2,4-triazole, n = 1, 0), demonstrates cooperative spin transition above room temperature. Under vacuum the complex loses its water molecules and shows an abrupt and reproducible spin transition with thermal… read more here.
Keywords: spin transition; spin; triazole; sif6 nh2o ... See more keywords
Molecular structure aspects and molecular reactivity of some triazole derivatives for corrosion inhibition of aluminum in 1 M HCl solution
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130292
Abstract: Abstract The corrosion inhibition of three triazole derivatives; p-tolyl-1H-1,2,3-triazol-5-ol (Z1), 4-Chlorophenyl-1H-1, 2, 3-triazol-5-ol (Z2) and Methyl-4-(5-hydroxy-1H-1, 2, 3-triazol-1-yl) benzoate (Z3) towards Aluminium metal in 1.0 M HCl have been investigated using potentiodynamic polarization, electrochemical impedance… read more here.
Keywords: triazole; triazole derivatives; corrosion inhibition; hcl ... See more keywords
Synthesis of novel 1,2,3-triazole based polycarboxylic acid functionalised ligands for MOF systems
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.01.014
Abstract: Abstract Copper catalysed click reactions are excellent tools to generate various 1,2,3-triazole linked polytopic aromatic carboxylates. The general reaction route involves protection of the carboxylates before proceeding with the click reaction. These polycarboxylate azoles are… read more here.
Keywords: triazole; based polycarboxylic; triazole based; structure ... See more keywords
Extension of Azine-Triazole Synthesis to Azole-Triazoles Reduces Ligand Field, Leading to Spin Crossover in Tris-L Fe(II).
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b02993
Abstract: The first examples of azole-triazole Rat ligands, bidentate L4NMeIm(3-(1-methyl-1H-imidazol-4-yl)-5-phenyl-4-(p-tolyl)-4H-1,2,4-triazole) and L4SIm (4-(5-phenyl-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thiazole), have been prepared, by extension of the general synthesis used to access many examples of azine-triazoles. The tris-L FeII complexes of the azine-triazoles… read more here.
Keywords: triazole; field; spin crossover; triazole complex ... See more keywords