Acute toxicity and antitumor potential of 1,3,4‐trisubstituted‐1,2,3‐triazole dhmtAc‐loaded liposomes on a triple‐negative breast cancer model
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200004
Abstract: For the first time, compounds developed from the 1,2,3‐triazole scaffold were evaluated as novel drugs to treat triple‐negative breast cancer (TNBC). Four organic salts were idealized as nonclassical bioisosteres of miltefosine, which is used in… read more here.
Keywords: triple negative; toxicity; triazole; dhmtac ... See more keywords
The current landscape of 1,2,3‐triazole‐(fused) six‐membered nitrogen‐containing heteroaromatic ring hybrids with anticancer therapeutic potential
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400873
Abstract: Cancer, characterized by uncontrolled growth and spread of abnormal cells potentially influencing almost all tissues in the body, is one of the most devastating and lethal diseases throughout the world. Chemotherapy is one of the… read more here.
Keywords: current landscape; cancer; landscape triazole; triazole fused ... See more keywords
Design and Synthesis of Nitrogen Rich Triazole‐based Mononuclear Ru(II) Arene Complexes Towards Anticancer Activities
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.202500300
Abstract: Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. Ruthenium complexes are emerging as a promising class of metal‐based drugs for cancer treatment, offering an… read more here.
Keywords: cancer; cell; metal; arene complexes ... See more keywords
Facile Synthesis of 5‐Halo‐1,2,3‐triazole‐fused Benzotricyclic Frameworks from 1‐(ω‐Azidoalkyl)‐2‐(2,2‐dihalovinyl)arenes and their Application in Fluorescent Triazole Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500355
Abstract: By heating 1‐(ω‐azidoalkyl)‐2‐(2,2‐dihalovinyl)arenes in DMF, intramolecular Huisgen cycloaddition between the azido group and the 1,1‐dihalovinyl moiety proceeded smoothly to afford 5‐halo‐1,2,3‐triazole‐fused tricyclic benzocondensed compounds. Leveraging the remaining halogen groups, carbon‐chain extension via Mizoroki–Heck or Suzuki–Miyaura… read more here.
Keywords: halo triazole; triazole fused; dihalovinyl arenes; azidoalkyl dihalovinyl ... See more keywords
1H-1,2,3-Triazole: From Structure to Function and Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2770
Abstract: The heterocyclic family of azoles have recently become one of the most widely used members of the N-heterocycles; the most prominent one being 1H-1,2,3-triazole and its derivatives. The sudden growth of interest in this structural… read more here.
Keywords: click chemistry; triazole; triazole structure; chemistry ... See more keywords
Microwave-assisted-demulsification dispersive liquid-liquid microextraction for the determination of triazole fungicides in water by gas chromatography with mass spectrometry.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201800860
Abstract: A novel microwave-assisted-demulsification dispersive liquid-liquid microextraction technique was established for determination of three triazole fungicides in environmental water samples by gas chromatography with mass spectrometry. Importantly, microwave irradiation has been applied in demulsification to achieve… read more here.
Keywords: liquid; triazole; demulsification; water ... See more keywords
1,2,3,-Triazole-Based Catalysts: From Metal- to Supramolecular Organic Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical record"
DOI: 10.1002/tcr.201600104
Abstract: 1,2,3-Triazoles are unique heterocycles with intriguing physical properties that allow not only the coordination to metals, but also the establishment of supramolecular interactions based on their polarized C-H bonds. In this account, an extensive work… read more here.
Keywords: metal supramolecular; triazole; catalysis; catalysts metal ... See more keywords
Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.028
Abstract: Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring closure generated novel 6-alkylfuro[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids (24b-37b),… read more here.
Keywords: triazole; pyrimidine one; chemistry; pyrimidine ... See more keywords
Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.057
Abstract: In this study, forty-four chiral triazole derivatives have been prepared via asymmetric synthesis, and which has been successfully characterized by typical spectroscopic techniques including 1H NMR, 13C NMR, EI-MS, elemental analysis and optical rotations. Their… read more here.
Keywords: triazole; triazole derivatives; vitro antiviral; asymmetric synthesis ... See more keywords
Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.020
Abstract: Currently, the available antifungal agents have significant clinical incompetency in terms of their clinical efficacy, antifungal spectrum, unfavorable pharmacokinetic profiles, substantial side effects and drug-drug interactions. Thus, the optimization and improvement of existing drugs and… read more here.
Keywords: alcohols derived; triazole; design; silico studies ... See more keywords
Cooperative spin transition in a 1D-polymeric complex [Fe(4-ethyl-1,2,4-triazole)3]SiF6·nH2O
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DOI: 10.1016/j.ica.2020.119560
Abstract: Abstract A new 1D-polymeric iron(II)-1,2,4-triazole complex, [Fe(EtTrz)3]SiF6·nH2O (EtTrz = 4-ethyl-1,2,4-triazole, n = 1, 0), demonstrates cooperative spin transition above room temperature. Under vacuum the complex loses its water molecules and shows an abrupt and reproducible spin transition with thermal… read more here.
Keywords: spin transition; spin; triazole; sif6 nh2o ... See more keywords