Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000220
Abstract: Although the 1,2,3‐triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully studied. Employing X‐ray crystallography and computational studies, we report the spatial and electronic… read more here.
Keywords: cystic fibrosis; fibrosis drugs; analogues cystic; amide bioisostere ... See more keywords
Design, synthesis, antimicrobial evaluation and docking studies of urea-triazole-amide hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128234
Abstract: Abstract A series of urea-1,2,3-triazole-amide hybrids was designed and synthesized via click reaction of urea derivatives containing a propargyl unit with 2-bromo-N-phenylacetamide derivatives and characterized by FTIR, NMR and HRMS data. The antimicrobial evaluation of… read more here.
Keywords: docking studies; antimicrobial evaluation; amide hybrids; urea triazole ... See more keywords