Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.11.056
Abstract: Abstract Several alkynes and azides were prepared starting from betulinic acid and Baylis-Hillman reaction-derived allylic alcohols. These alkynes and azides were then coupled under click cycloaddition conditions to obtain functionalized betulinic acid-triazole conjugates. Similarly, pyrazinyl-… read more here.
Keywords: acid triazole; baylis hillman; betulinic acid; acid ... See more keywords
Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections
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DOI: 10.1021/acsomega.1c05303.s001
Abstract: A newer ciprofloxacin series containing 1,2,3-triazole conjugates of ciprofloxacin was designed, synthesized, and well characterized using modern analytical techniques by reacting diversified anilines with ciprofloxacin obtained from ciprofloxacin hydrochloride. The newer conjugates were evaluated for… read more here.
Keywords: compound; ciprofloxacin tethered; clinical isolate; typhi clinical ... See more keywords
Click-designed vanilloid-triazole conjugates as dual inhibitors of AChE and Aβ aggregation
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DOI: 10.1039/d2ra07539c
Abstract: Based on their reported neuroprotective properties, vanilloids provide a good starting point for the synthesis of anti-Alzheimer's disease (AD) agents. In this context, nine new 1,2,3-triazole conjugates of vanilloids were synthesized via click chemistry. The… read more here.
Keywords: triazole esters; ache aggregation; triazole conjugates; kcal mol ... See more keywords
Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
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DOI: 10.1515/acph-2017-0024
Abstract: Abstract The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the… read more here.
Keywords: green ultrasound; three component; fluorinated triazole; click ... See more keywords
QSAR and Molecular Docking Studies of Pyrimidine-Coumarin-Triazole Conjugates as Prospective Anti-Breast Cancer Agents
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061845
Abstract: Cancer is a life-threatening disease and is the second leading cause of death worldwide. Although many drugs are available for the treatment of cancer, survival outcomes are very low. Hence, rapid development of newer anticancer… read more here.
Keywords: pyrimidine coumarin; breast cancer; triazole conjugates; coumarin triazole ... See more keywords