Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5‐Diphenyl‐1H‐1,2,4‐Triazole Derivatives as Potential hEGFR Inhibitors
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DOI: 10.1002/ardp.70007
Abstract: EGFR, an important target in cancer chemotherapy, is an important component of the signaling system that regulates important cellular processes such as growth, differentiation, metabolism, and apoptosis in response to both internal and external stimuli.… read more here.
Keywords: synthesis vitro; triazole derivatives; evaluation molecular; diphenyl triazole ... See more keywords
Discovery of novel acrylopimaric acid triazole derivatives as promising antifungal agents
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DOI: 10.1002/ps.8102
Abstract: To further develop potential natural fungicides, two series of new acrylopimaric acid triazole derivatives were synthesized, and their antifungal activities were tested and evaluated. read more here.
Keywords: acrylopimaric acid; triazole derivatives; acid triazole; discovery novel ... See more keywords
Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives
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DOI: 10.1007/s10593-018-2319-6
Abstract: New 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives have been synthesized by a CuAAC reaction and their antibacterial and antifungal activity has been evaluated. Some of the derivatives showed remarkable in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas… read more here.
Keywords: methyl triazole; aryl fructopyranos; design synthesis; fructopyranos methyl ... See more keywords
Synthesis of 1,2,3-Triazole Derivatives from 2,3-Dienoates of Methyl Maleopimarate
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DOI: 10.1007/s10600-017-1984-5
Abstract: Hybrid compounds based on N-maleopimarimides containing a triazole-ring pharmacophore were prepared via 1,3-dipolar cycloaddition of methyl-2-azidoacetate to allenoates. read more here.
Keywords: triazole derivatives; derivatives dienoates; synthesis triazole; dienoates methyl ... See more keywords
Synthesis and fluorescence properties of nicotinonitrile 1,2,3-triazole derivatives
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DOI: 10.1007/s11172-018-2280-7
Abstract: A three-component condensation of 1,2,3-triazole chalcones, malononitrile, and sodium alkoxides afforded 6- and 4-(1,2,3-triazol-4-yl)substituted nicotinonitriles in 44–78% yields, possessing pronounced fluorescent properties. The quantitative characteristics of fluorescence were assessed, the relationship between the nature of… read more here.
Keywords: nicotinonitrile triazole; fluorescence; triazole derivatives; properties nicotinonitrile ... See more keywords
Cell cycle inhibition, apoptosis, and molecular docking studies of the novel anticancer bioactive 1,2,4-triazole derivatives
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DOI: 10.1007/s11224-019-01453-3
Abstract: Several 3-alkylsulfanyl-1,2,4-triazole derivatives were synthesized and their relevant structures confirmed based on their elemental analysis and nuclear magnetic resonance. The anticancer activity of all the derivatives was evaluated for A549, MCF7, and SKOV3 cell lines… read more here.
Keywords: docking studies; triazole derivatives; cell cycle; cell ... See more keywords
Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis.
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DOI: 10.1016/j.bioorg.2021.104867
Abstract: To enhance the disruption of Hsp90-Cdc37, we designed and synthesized a series (27) of CEL-triazole derivatives. Most of the target compounds showed enhanced anti-proliferative activity on four cancer cell lines (MDA-MB-231, MCF-7, HepG2 and A459).… read more here.
Keywords: triazole derivatives; cell apoptosis; tumor cell; compound ... See more keywords
Synthesis and gelation property of a series of disaccharide triazole derivatives.
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DOI: 10.1016/j.carres.2017.09.008
Abstract: Low molecular weight gelators are important for the study of supramolecular chemistry and have useful applications for biomaterials. Glycomimetics that are easily accessible and have useful gelation properties are especially interesting molecules. In this research,… read more here.
Keywords: gelation; gelation property; triazole derivatives; disaccharide triazole ... See more keywords
Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.057
Abstract: In this study, forty-four chiral triazole derivatives have been prepared via asymmetric synthesis, and which has been successfully characterized by typical spectroscopic techniques including 1H NMR, 13C NMR, EI-MS, elemental analysis and optical rotations. Their… read more here.
Keywords: triazole; triazole derivatives; vitro antiviral; asymmetric synthesis ... See more keywords
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112114
Abstract: A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the… read more here.
Keywords: evaluation triazole; biological evaluation; triazole derivatives; compound ... See more keywords
Molecular structure aspects and molecular reactivity of some triazole derivatives for corrosion inhibition of aluminum in 1 M HCl solution
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130292
Abstract: Abstract The corrosion inhibition of three triazole derivatives; p-tolyl-1H-1,2,3-triazol-5-ol (Z1), 4-Chlorophenyl-1H-1, 2, 3-triazol-5-ol (Z2) and Methyl-4-(5-hydroxy-1H-1, 2, 3-triazol-1-yl) benzoate (Z3) towards Aluminium metal in 1.0 M HCl have been investigated using potentiodynamic polarization, electrochemical impedance… read more here.
Keywords: triazole; triazole derivatives; corrosion inhibition; hcl ... See more keywords