Facile synthesis of 1,2,3-triazole-fused indolo- and pyrrolo[1,4]diazepines, DNA-binding and evaluation of their anticancer activity.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103306
Abstract: A facile synthetic strategy has been developed for the generation of structurally diverse N-fused heterocycles. The formation of fused 1,2,3-triazole indolo and pyrrolodiazepines proceeds through an initial Knoevenagel condensation followed by intramolecular azide-alkyne cycloaddition reaction… read more here.
Keywords: fused indolo; facile synthesis; triazole fused; synthesis triazole ... See more keywords
A new route to 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues through metal-free intramolecular azide-olefin oxidative cycloaddition
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151164
Abstract: Abstract A collection of 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues was prepared by one pot azide substitution and intramolecular azide-olefin oxidative cycloaddition sequence under metal-free conditions. read more here.
Keywords: benzooxazepine benzodiazepine; intramolecular azide; azide olefin; triazole fused ... See more keywords
Synthesis of Triazole-Fused Phenanthridines through Pd-Catalyzed Intramolecular Phenyl C–H Activation of 1,5-Diaryl-1,2,3-triazoles
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DOI: 10.1055/s-0037-1611859
Abstract: An efficient method for the synthesis of triazole-fused phenanthridines from 1,5-diaryl-1,2,3-triazoles under palladium catalysis has been developed. The reaction proceeds through Pd-catalyzed intramolecular phenyl C–H activation of 1,5-diaryl-1,2,3-triazoles. This method provides a concise and efficient… read more here.
Keywords: fused phenanthridines; synthesis triazole; intramolecular phenyl; catalyzed intramolecular ... See more keywords
Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154681
Abstract: Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite… read more here.
Keywords: applications triazole; syntheses applications; fused pyrazines; chemistry ... See more keywords