Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200023
Abstract: Leishmaniasis is a vector‐borne neglected parasitic infection affecting thousands of individuals, mostly among populations in low‐ to moderate‐income developing countries. In the absence of protective vaccines, the management of the disease banks solely on chemotherapy.… read more here.
Keywords: nitrofurantoin triazole; synthesis vitro; efficacy hit; vitro antileishmanial ... See more keywords
Ciprofloxacin‐isatin‐1H‐1,2,3‐triazole Hybrids: Design, Synthesis, and in vitro Anti‐tubercular Activity against M. tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3010
Abstract: A new set of ciprofloxacin (CPFX)-isatin-1H-1,2,3-triazole hybrids 6a–l with greater lipophilicity compared with the parent CPFX was designed, synthesized, and assessed for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis (MTB) H37Rv as well as… read more here.
Keywords: isatin triazole; triazole hybrids; vitro anti; ciprofloxacin ... See more keywords
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02553-0
Abstract: Infectious diseases such as tuberculosis and leishmaniasis are leading causes of human death. One of the major factors contributing to the poor control of these diseases is primarily the reduced effectiveness of the existing chemotherapies… read more here.
Keywords: vitro antimycobacterial; triazole hybrids; hydroquinone triazole; chemistry ... See more keywords
Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102967
Abstract: A series of 12 novel 1,4-naphthoquinone-1,2,3-triazole hybrids were designed and synthesized through copper-catalyzed click reaction of 2-(prop-2-ynylamino)naphthalene-1,4-dione (3) and different azidomethyl-benzene derivatives. The synthesized compounds were assessed for their anticancer activity against three cancer cell… read more here.
Keywords: triazole hybrids; chemistry; cell cycle; cancer cell ... See more keywords
New thiosemicarbazide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: Design, synthesis, and biological evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.04.082
Abstract: Abstract A new series of thiosemicarbazide-1,2,3-triazole hybrids 10a-o has been synthesized, characterized by 1H NMR, 13C NMR, and screened for their in vitro α-glucosidase inhibitory activity. All of the synthesized compounds displayed excellent α-glucosidase inhibitory activity… read more here.
Keywords: hybrids potent; new thiosemicarbazide; potent glucosidase; compound 10h ... See more keywords
Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c06531
Abstract: Cancer is the most severe disease worldwide. Every year, tens of millions of people are diagnosed with cancer, and over half of those people will ultimately die from the disease. Hence, the discovery of new… read more here.
Keywords: liver cancer; cancer cells; indolyl triazole; triazole hybrids ... See more keywords
Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07993
Abstract: Coumarin is a naturally occurring bioactive pharmacophore with wide occurrence among central nervous system (CNS)-active small molecules. 8-Acetylcoumarin, one of the natural coumarins, is a mild inhibitor of cholinesterases and β-secretase, which are vital targets… read more here.
Keywords: synthesis biological; biological evaluation; coumarin; triazole hybrids ... See more keywords
New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214291
Abstract: Resistance to antibiotics is an emerging problem worldwide, which leads to an increase in morbidity and mortality rates. Several mechanisms are attributed to bacterial resistance, overexpression of efflux pumps being one of the most prominent.… read more here.
Keywords: chalcone triazole; activity; resistance; new chalcone ... See more keywords
Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020626
Abstract: Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were… read more here.
Keywords: vitro anticancer; synthesis vitro; flavone triazole; triazole hybrids ... See more keywords
Inhibition of α-glucosidase enzyme by 'click'-inspired pharmacophore framework 1,3,4-thiadiazole-1,2,3-triazole hybrids.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0289
Abstract: Aim: α-Glucosidase inhibitors are important oral antidiabetic drugs that are used alone or in combination therapy. Materials & methods: In this regard, 1,3,4-thiadiazoles-1,2,3-triazoles were designed, synthesized and evaluated for α-glucosidase enzyme inhibition. Results: The applied… read more here.
Keywords: inhibition; glucosidase; click inspired; thiadiazole triazole ... See more keywords