1,2,3‐Triazole‐linked 5‐benzylidene (thio)barbiturates as novel tyrosinase inhibitors and free‐radical scavengers
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000058
Abstract: In this study, benzyl‐1,2,3‐triazole‐linked 5‐benzylidene (thio)barbiturate derivatives 7a–d and 8a–h were designed as potential tyrosinase inhibitors and free‐radical scavengers. The twelve derivatives were synthesized via the [3+2] cycloaddition reaction of the corresponding benzyl azide as… read more here.
Keywords: linked benzylidene; triazole linked; tyrosinase inhibitors; free radical ... See more keywords
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
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DOI: 10.1002/cmdc.201700786
Abstract: Protozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery… read more here.
Keywords: library triazole; triazole linked; focused library; phenotypic ... See more keywords
Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.002
Abstract: A series of twenty four hydroxy-trifluoromethylpyrazoline-carbonyl-1,2,3-triazoles and four hydrazones bearing benzenesulfonamide moieties was obtained by condensation of carboxyhydrazides with substituted 1,3-diketones. All the newly synthesized compounds were investigated as inhibitors of physiologically and pharmacologically relevant… read more here.
Keywords: synthesis novel; benzenesulfonamide bearing; triazole linked; linked hydroxy ... See more keywords
Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.070
Abstract: Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging global health concern leading to increasing morbidity and mortality. Continuous increase in drug resistance has underlined the need for discovery and development of new antibacterial… read more here.
Keywords: staphylococcus; staphylococcus aureus; triazole linked; antibacterial agents ... See more keywords
A new multi-functional fluorescent mercuric ion sensor based on diarylethene with triazole-linked rhodamine B unit
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131393
Abstract: Abstract A novel photochromic diarylethene fluorescence sensor 1o bearing a triazole-linked rhodamine B unit was designed and synthesized. Results showed that 1o had multi-responsive photoswitchable characteristics under the stimulation of light, proton, and specific metal… read more here.
Keywords: rhodamine unit; unit; fluorescence; triazole linked ... See more keywords
Synthesis and biological properties of triazole-linked locked nucleic acid.
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DOI: 10.1039/c7cc04092j
Abstract: We have synthesized and studied the biological and biophysical properties of triazole-linked ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole linkage gave high binding affinity when incorporated at… read more here.
Keywords: triazole linked; properties triazole; synthesis biological; nucleic acid ... See more keywords
Spacer effect on triazole-linked sugar-based surfactants
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DOI: 10.1080/01932691.2016.1144513
Abstract: ABSTRACT A series of alkyl triazole glycoside surfactants, ATGs, differing in the length of the alkyl linker between the sugar and the triazole, was synthesized and investigated on their surfactant properties and phase behavior in… read more here.
Keywords: triazole; effect triazole; triazole linked; spacer effect ... See more keywords
New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2072308
Abstract: Abstract A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67–62.47 µM, and 4.19–24.37 µM for… read more here.
Keywords: linked ciprofloxacin; dna damage; ciprofloxacin chalcones; triazole linked ... See more keywords
Triazole-linked nucleic acids: Synthesis, therapeutics and synthetic biology applications.
Sign Up to like & getrecommendations! Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230502123950
Abstract: This article covers the triazole-linked nucleic acids where the triazole linkage (TL) replaces the natural phosphate backbone. The replacement is done at either a few selected linkages or all the phosphate linkages. Two triazole linkages,… read more here.
Keywords: linked nucleic; triazole linked; nucleic acids; biology ... See more keywords