Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2077731
Abstract: Abstract A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or… read more here.
Keywords: a2a a2b; dual a2a; pyrimidine methylbenzonitrile; triazole pyrimidine ... See more keywords
Functionalization of 1,2,3-Triazole to Pyrimidine, Pyridine, Pyrazole, and Isoxazole Fluorophores with Antimicrobial Activity
Sign Up to like & getrecommendations! Published in 2020 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363220030226
Abstract: Abstract The multi-component reaction of diacetyl triazole derivative with ethyl cyanoacetate and various aromatic aldehydes according to the conventional and solvent free methods leads to the corresponding 2-oxonicotinonitriles. A number of chalcones has been obtained… read more here.
Keywords: functionalization triazole; antimicrobial activity; triazole pyrimidine; activity ... See more keywords