Application of chiral triazole-substituted iodoarenes in the enantioselective construction of spirooxazolines.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03246a
Abstract: A catalytic highly enantioselective synthesis of spirooxazolines is presented. Starting from readily available 2-naphthol-substituted benzamides and using catalytic amounts of a chiral triazole-substituted iodoarene catalyst, a variety of spirooxazolines can be isolated through an enantioselective… read more here.
Keywords: application chiral; triazole substituted; substituted iodoarenes; chiral triazole ... See more keywords
Synthesis of 1,2,3-triazole-substituted 6,7-dihydroindolizin-8(5H)-one derivatives mediated by Selectfluor
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Research"
DOI: 10.1177/1747519819857478
Abstract: The 1,2,3-triazole and 1H-1,2,3-benzotriazole-substituted 6,7-dihydroindolizin-8(5H)-one derivatives were synthesized by the reaction of (E)-7-(arylmethylidene)-6,7-dihydroindolizin-8(5H)-ones with 1,2,3-triazole and 1H-1,2,3-benzotriazole in the presence of Selectfluor in moderate yield. The structures of all the products were characterized thoroughly by… read more here.
Keywords: dihydroindolizin one; triazole substituted; one derivatives; derivatives mediated ... See more keywords
Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30122641
Abstract: 6-Aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines have promising properties as colony-stimulating factor 1 receptor (CSF1R) inhibitors. Inspired by these antagonists, two series of 1,2,3-triazole analogues (28 compounds) were synthesized and evaluated as CSF1R inhibitors. Enzymatic IC50 profiling showed that 27… read more here.
Keywords: triazole substituted; pyrrolopyrimidines csf1r; substituted pyrrolopyrimidines; evaluating triazole ... See more keywords