Synthesis of new triazole tethered derivatives of curcumin and their antibacterial and antifungal properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1524-7
Abstract: New derivatives of curcumin connected to 1,2,3-triazole ring were synthesized by Knoevenagel reaction of the middle carbon with aromatic aldehydes, followed by alkyne-azide 1,3-dipolar cycloaddition. These new compounds were evaluated for their antimicrobial activity against… read more here.
Keywords: antibacterial antifungal; tethered derivatives; new triazole; synthesis new ... See more keywords
Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.060
Abstract: The series of 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles 5a-t were synthesized from corresponding 2-amino-7-phydroxy-4H-chromene-3-carbonitriles 4a-t and propargyl bromide. Two procedures were used in these syntheses: K2CO3/acetone and NaH/DMF procedures with yields of 65-89% and 80-96%, respectively. 1H-1,2,3-Triazole-tethered 4H-chromene-d-glucose conjugates… read more here.
Keywords: chromene; chromene glucose; chemistry; tethered chromene ... See more keywords
Design, synthesis, anti-proliferative evaluation and docking studies of 1H-1,2,3-triazole tethered ospemifene–isatin conjugates as selective estrogen receptor modulators
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DOI: 10.1039/c7nj04964a
Abstract: A library of 1H-1,2,3-triazole-tethered ospemifene–isatin and ospemifene–spiroisatin conjugates have been synthesized and evaluated for their anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. The evaluation studies revealed that compound 11j was the most potent with… read more here.
Keywords: tethered ospemifene; anti proliferative; docking studies; evaluation ... See more keywords