1,3,4‐Thiadiazole and 1,2,4‐triazole‐5‐thione derivatives bearing 2‐pentyl‐5‐phenyl‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐one ring: Synthesis, molecular docking, urease inhibition, and crystal structure
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200355
Abstract: Two series of 1,3,4‐thiadiazole (40a–o) and 1,2,4‐triazole‐5‐thione (41a–l) derivatives bearing a 2‐pentyl‐5‐phenyl‐1,2,4‐triazole‐3‐one ring were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. Among the two groups, the first… read more here.
Keywords: crystal; inhibition; activity; phenyl ... See more keywords
1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors.
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DOI: 10.1002/cmdc.202100699
Abstract: Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-negative pathogens. Unfortunately, clinically efficient MBL inhibitors still represent an unmet medical need . We previously reported several series… read more here.
Keywords: triazole thione; metallo; vim; vim type ... See more keywords
Hydrophobic pocket docking, double-proton prototropic tautomerism in contradiction to single-proton transfer in thione ⇔thiol Schiff base with triazole-thione moiety: Green synthesis, XRD and DFT-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.12.010
Abstract: Abstract In the present study, an eco-friendly and efficient microwave-assisted synthesis of the (E)-4-((3,4-difluorobenzylidene)amino)-2,4-dihydro-5-methyl-3H-1,2,4-triazole-3-thione Schiff base ligand was described. XRD-single crystal analysis reflected the molecule occurs in an exo-thione tautomeric form in solid state. Therefore,… read more here.
Keywords: xrd; thione; proton; triazole thione ... See more keywords
An investigation of supramolecular synthons in 1,2,4-triazole-3(4H)-thione compounds. X-ray crystal structures, energetic and Hirshfeld surface analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.049
Abstract: Abstract A series of four closely related 1,2,4-triazole-3-thione (1-4) compounds was obtained by heterocyclization of thiosemicarbazides under basic catalytic conditions. The crystal structures of the 4-alkyl-5-(substituted-phenyl)-2H-1,2,4-triazole-3(4H)-thione derivatives [4-alkyl = 4-ethyl-5-phenyl (1), 4-hexyl-5-phenyl (2), 4-hexyl-5-p-tolyl (3), and 4-ethyl-5-(2,4,6-trimethoxyphenyl)… read more here.
Keywords: thione compounds; surface; thione; crystal structures ... See more keywords
The in vitro anticancer activity and potential mechanism of action of 1-[(1R,2S)-2-fluorocyclopropyl]ciprofloxacin-(4-methyl/phenyl/benzyl-3-aryl)-1,2,4-triazole-5(4H)-thione hybrids.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200310123723
Abstract: AIMS To develop novel anticancer candidates which are sensitive to both drug-sensitive and drug-resistant cancers, a series of 1-[(1R, 2S)-2-fluorocyclopropyl]ciprofloxacin-(4-methyl/phenyl/benzyl-3-aryl)-1,2,4-triazole-5(4H)-thione hybrids were designed, synthesized and evaluated for their anticancer activity. BACKGROUND Chemotherapy is an essential… read more here.
Keywords: thione hybrids; fluorocyclopropyl ciprofloxacin; drug; triazole thione ... See more keywords
Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione
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DOI: 10.3390/molecules28062718
Abstract: The treatment of infectious diseases is a challenging issue faced by the medical community. The emergence of drug-resistant strains of bacteria and fungi is a major concern. Researchers and medical professionals are working to develop… read more here.
Keywords: schiff bases; triazole thione; synthesis biological; amino fluorophenyl ... See more keywords
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13030052
Abstract: The emergence of bacteria that co-express serine- and metallo- carbapenemases is a threat to the efficacy of the available β-lactam antibiotic armamentarium. The 4-amino-1,2,4-triazole-3-thione scaffold has been selected as the starting chemical moiety in the… read more here.
Keywords: serine metallo; amino triazole; triazole thione; metallo ... See more keywords