Design and synthesis of 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900002
Abstract: A series of 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives was designed, synthesized, and screened for their phosphodiesterase (PDE 4B) inhibitory activity and bronchodilation ability. Compound 7e showed 41.80% PDE 4B inhibition at 10 µM. Eight compounds were screened for their… read more here.
Keywords: bronchodilator activity; triazolo pyrimidine; activity; pyrimidine derivatives ... See more keywords
Synthesis of functionalized triazolo[1,5-a]pyrimidine derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2230-1
Abstract: New triazolo[1,5-a]pyrimidines containing aroyl and acetyl or ester groups in the pyrimidine ring were synthesized in a process related to the Biginelli-like reaction, using hydrates of arylglyoxals, β-dicarbonyl compounds, and 1H-1,2,4-triazol-5-amine. Reaction was carried out… read more here.
Keywords: triazolo pyrimidine; synthesis functionalized; chemistry; pyrimidine derivatives ... See more keywords
A convenient route to the 1,2,5-oxadiazole-substituted 1,2,4-triazolo[1,5-a]pyrimidine derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02590-7
Abstract: A convenient synthesis of 1,2,4-triazole and 1,2,4-triazolo[1,5-a]pyrimidines with 3-amino-1,2,5-oxadiazole substituent starting from available 4-amino-1,2,5-oxadiazole-3-carbohydrazide and benzoyl cyanamide has been developed. read more here.
Keywords: route oxadiazole; triazolo pyrimidine; pyrimidine derivatives; substituted triazolo ... See more keywords
Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111824
Abstract: In searching for more effective and safer antiepileptic drugs, a series of 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine-7(4H)-one derivatives were designed and synthesized. Spontaneous Ca2+ oscillations (SCOs) of cortical neurons were used for in vitro phenotypic screening. Maximal electroshock test… read more here.
Keywords: triazolo pyrimidine; anticonvulsant activity; pyrimidine one; one derivatives ... See more keywords
Solvent induced supramolecular polymorphism in Cu(II) coordination complex built from 1,2,4-triazolo[1,5-a]pyrimidine: Crystal structures and anti-oxidant activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111092
Abstract: Two Cu(II) coordination complexes, C1 and C2 of the formula [Cu(4)2(H2O)2], have been prepared by reaction between CuCl2·2H2O and 7-ethoxycarbonylmethyl-5-methyl-1,2,4[1,5-a]pyrimidine (L) in a 1:2 M:L molar ratio. The L molecule decomposes during the reaction process… read more here.
Keywords: triazolo pyrimidine; coordination; pyrimidine; solvent induced ... See more keywords
In vitro leishmanicidal activity of copper (II) 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine complex and analogous transition metal series
Sign Up to like & getrecommendations! Published in 2020 at "Polyhedron"
DOI: 10.1016/j.poly.2019.114272
Abstract: Abstract A series of triazolopyrimidine transition metals complexes have been synthesized by the reaction between the derivative 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) with M(NO3)2·XH2O (M = Cu(II), Co(II), Ni(II) and Zn(II)). These four compounds have been characterized by spectroscopic and… read more here.
Keywords: triazolo pyrimidine; series; dimethyl triazolo; transition ... See more keywords
Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra01968j
Abstract: CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the privileged pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffolds (4–13) as well as the… read more here.
Keywords: triazolo pyrimidine; pyrazolo triazolo; pyrazolo pyrimidine; activity ... See more keywords
Synthesis and characterization of thiophene-derived palladium(ii) complex immobilized on FSM-16 and its application in the novel synthesis of 7-(aryl)-7,12-dihydro-6H-indeno[1,2,4]triazolo[1,5-a]pyrimidine-6-one derivatives
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra06271b
Abstract: The present study aims at synthesizing a palladium complex with a thiophene-carboimine ligand, supported on FSM-16 as a mesoporous silica support. Firstly, the prepared FSM-16 was modified using 3-aminopropyl group. The imine bond was subsequently… read more here.
Keywords: indeno triazolo; triazolo pyrimidine; thiophene; synthesis ... See more keywords
Synthesis of Polyheterocyclic Ring Systems Included Triazolo[1,5-a]Pyrimidine as Antioxidant Agents
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1750042
Abstract: The highly versatile 6-cyano-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine (6) has been synthesized and utilized as a building block for the design of new tricyclic and tetracyclic ring system... read more here.
Keywords: triazolo pyrimidine; synthesis polyheterocyclic; ring systems; pyrimidine ... See more keywords
Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154996
Abstract: [1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization strategy. The antiproliferative activities of the… read more here.
Keywords: erk signaling; pyrimidine indole; triazolo pyrimidine; signaling pathway ... See more keywords