Design, synthesis, in silico ADMET, docking, and antiproliferative evaluations of [1,2,4]triazolo[4,3‐c]quinazolines as classical DNA intercalators
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DOI: 10.1002/ardp.202100412
Abstract: Eleven novel [1,2,4]triazolo[4,3‐c]quinazolines were designed, synthesized, and evaluated against HepG2 and HCT‐116 cells. The molecular design was performed to investigate the binding mode of the proposed compounds with the DNA active site. The data obtained… read more here.
Keywords: design synthesis; dna; silico admet; synthesis silico ... See more keywords
New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
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DOI: 10.1371/journal.pone.0274081
Abstract: Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was… read more here.
Keywords: silico studies; topo inhibitors; new triazolo; triazolo quinazolines ... See more keywords
3-Aryl-5-aminobiphenyl Substituted [1,2,4]triazolo[4,3-c]quinazolines: Synthesis and Photophysical Properties
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DOI: 10.3390/molecules28041937
Abstract: Amino-[1,1′]-biphenyl-containing 3-aryl-[1,2,4]triazolo[4,3-c]quinazoline derivatives with fluorescent properties have been designed and synthesized. The type of annelation of the triazole ring to the pyrimidine one has been unambiguously confirmed by means of an X-ray diffraction (XRD) method;… read more here.
Keywords: substituted triazolo; aryl aminobiphenyl; emission; triazolo quinazolines ... See more keywords