157 Myeloid expression of trib1 regulates the polarisation state of tissue resident macrophages that has consequences on plasma lipid and metabolic homeostasis
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DOI: 10.1136/heartjnl-2017-311726.156
Abstract: Introduction Genome wide association studies have identified Tribbles-1 (TRIB1) to be significantly associated with all major plasma lipid traits and as a risk factor for ischaemic heart disease and myocardial infarction. Studies in mice using… read more here.
Keywords: homeostasis; trib1; expression trib1; expression ... See more keywords
BS25 Investigating the MIR-101-3P/TRIB1 axis in macrophage immunometabolism
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DOI: 10.1136/heartjnl-2019-bcs.188
Abstract: Introduction MiR-101-3p has been implicated in the regulation of macrophage cholesterol efflux and pro-inflammatory genes by directly targeting ABCA1 and MKP-1, which are both downregulated in atherosclerosis. By using bioinformatic analysis we identified TRIB1 as… read more here.
Keywords: trib1; 101 trib1; macrophage immunometabolism; mir 101 ... See more keywords
Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9.
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DOI: 10.1182/blood.2019004586
Abstract: The pseudokinase Trib1 functions as a myeloid oncogene that recruits the E3 ubiquitin ligase COP1 to C/EBPa and interacts with MEK1 to enhance ERK phosphorylation. Close genetic effect of Trib1 on Hoxa9 has been observed… read more here.
Keywords: trib1 promotes; myeloid leukemia; hoxa9; trib1 ... See more keywords