Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30860
Abstract: Aim was to identify methylated genes with functional involvement in cisplatin‐resistance development of epithelial ovarian cancer (EOC). Genome‐wide analyses of hypermethylated CpG‐islands in resistant cell lines in combination with qRT‐PCR analyses were used to identify… read more here.
Keywords: epithelial ovarian; cisplatin; expression; ovarian cancer ... See more keywords
Long non-coding RNA MEG3 inhibits chondrogenic differentiation of synovium-derived mesenchymal stem cells by epigenetically inhibiting TRIB2 via methyltransferase EZH2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109379
Abstract: Osteoarthritis (OA) is a highly prevalent skeletal disease. Mesenchymal stem cell-derived cartilage tissue engineering is a clinical method used for OA treatment. Investigations on the molecular regulatory mechanisms of the chondrogenic differentiation of synovium-derived mesenchymal… read more here.
Keywords: meg3; chondrogenic differentiation; trib2; mesenchymal stem ... See more keywords
TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14687
Abstract: Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. Here we report that tribbles… read more here.
Keywords: protein; akt; drug resistance; resistance ... See more keywords
TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00574-1
Abstract: Tribbles homolog 2 (TRIB2) is known to boost liver tumorigenesis via regulating Ubiquitin (Ub) proteasome system (UPS). At least two ways are involved, i.e., acts as an adaptor protein to modulate ubiquitination functions of certain… read more here.
Keywords: ferroptosis; trcp; liver cancer; trib2 ... See more keywords
E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure
Sign Up to like & getrecommendations! Published in 2025 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2024.2434058
Abstract: Abstract Objective Heart failure (HF) causes structural and functional changes in the heart, with the pyroptosis-mediated inflammatory response as the core link in HF pathogenesis. E3 ubiquitin ligases participate in cardiovascular disease progression. Here, we… read more here.
Keywords: degradation; pyroptosis; heart; cardiomyocyte pyroptosis ... See more keywords
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aat7951
Abstract: Covalent EGFR family inhibitors bind to and induce the degradation of the pseudokinase TRIB2 to kill cancer cells. Targeting pseudokinases with kinase inhibitors Pseudokinases are structurally similar to kinases but lack catalytic activity; instead, pseudokinases… read more here.
Keywords: degradation; family; cancer cells; cancer ... See more keywords