TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARĪ± and Inhibition of p53-Mediated Senescence.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.006
Abstract: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML-RARĪ±, which antagonizes myeloid differentiation and promotes APL-initiating cell self-renewal. Combined all-trans retinoic acid (ATRA) with arsenic trioxide (As2O3) or chemotherapy dramatically improves the prognosis of… read more here.
Keywords: rar; trib3; promotes apl; oncoprotein pml ... See more keywords
TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10601-w
Abstract: Osteogenic differentiation in human bone marrow-derived mesenchymal stem cells (hBMSCs) is regulated by various factors, including bone morphogenetic proteins (BMPs), Notch, growth hormones and mitogen-activated protein kinases (MAPKs). Tribbles homolog 3 (TRIB3), a pseudokinase, plays… read more here.
Keywords: trib3; kinase; proliferation; differentiation ... See more keywords
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abf0992
Abstract: Description TRIB3 promotes exclusion of CD8+ T cells and enhances immune evasion by inhibiting the STAT1-CXCL10 signaling axis in colorectal cancer. Turning up the temperature on cold tumors Abundant CD8+ T cell infiltration into colorectal… read more here.
Keywords: cell; cell infiltration; cd8 cell; trib3 ... See more keywords
Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.948461
Abstract: Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development.… read more here.
Keywords: extracellular matrix; fibrous cap; matrix remodelling; trib3 ... See more keywords
Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13102341
Abstract: Simple Summary Proteasome inhibitors are currently used in the treatment of certain blood cancers, and clinical trials to treat solid tumors, including liver cancer, have also been conducted. However, different malignancies are not equally susceptible… read more here.
Keywords: inhibitor; trib3; bortezomib; resistance ... See more keywords
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415705
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase… read more here.
Keywords: ipf; atf4; fibroblast activation; trib3 ... See more keywords