The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.03.002
Abstract: The eukaryotic chaperonin TRiC/CCT is a large hetero-oligomeric complex that plays an essential role assisting cellular protein folding and suppressing protein aggregation. It consists of two rings, and each composed of eight different subunits; non-native… read more here.
Keywords: atp powered; protein folding; tric cct; powered gymnastics ... See more keywords
Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT
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DOI: 10.1101/2022.07.25.501395
Abstract: The eukaryotic chaperonin TRiC/CCT assists the folding of ~10% cytosolic proteins. The essential cytoskeletal proteins tubulin and actin are the obligate substrates of TRiC and their folding involves cochaperone and co-factors. Here, through cryo-EM analysis,… read more here.
Keywords: state; structural basis; plp2; tric cct ... See more keywords
Chaperonin TRiC/CCT Participates in Mammarenavirus Multiplication in Human Cells via Interaction with the Viral Nucleoprotein
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DOI: 10.1128/jvi.01688-22
Abstract: Host-directed antivirals have gained great interest as an antiviral strategy to counteract the rapid emergence of drug-resistant viruses. The chaperonin TRiC/CCT complex has been involved in the life cycle of several viruses, including dengue, Zika,… read more here.
Keywords: chaperonin tric; multiplication; cct; tric cct ... See more keywords
Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila
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DOI: 10.1371/journal.pgen.1008121
Abstract: Endocycle is a commonly observed cell cycle variant through which cells undergo repeated rounds of genome DNA replication without mitosis. Endocycling cells arise from mitotic cells through a switch of the cell cycle mode, called… read more here.
Keywords: drosophila; mechanisms mes; endocycle; regulatory mechanisms ... See more keywords