Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.01.061
Abstract: This work describes a novel methodology to analyze four tricyclic antidepressants (amitriptyline, doxepin, imipramine and, nortriptyline) in urine samples by combining supramolecular microextraction and paper spray ionization mass spectrometry (PS-MS). The proposed method uses a… read more here.
Keywords: mass spectrometry; supramolecular microextraction; mass; paper spray ... See more keywords
Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.048
Abstract: The purpose of this study was to evaluate the skin permeation of tricyclic antidepressants (TCAs) with propamine moiety to select candidates for the development of topical analgesics to treat cutaneous pain. We sought to establish… read more here.
Keywords: structure permeation; tcas; permeation; tricyclic antidepressants ... See more keywords
Biomarkers as predictors of treatment response to tricyclic antidepressants in major depressive disorder: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2022.03.057
Abstract: Tricyclic antidepressants (TCAs) are frequently prescribed in case of non-response to first-line antidepressants in Major Depressive Disorder (MDD). Treatment of MDD often entails a trial-and-error process of finding a suitable antidepressant and its appropriate dose.… read more here.
Keywords: major depressive; response; tricyclic antidepressants; antidepressants major ... See more keywords
Intermolecular interactions between natural humic substances and tricyclic antidepressants
Sign Up to like & getrecommendations! Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.07.024
Abstract: Intermolecular interactions between humic substances (HSs) and the tricyclic antidepressants (TAs) amitriptyline, nortriptyline, imipramine and desipramine were detected for the first time by fluorescence spectroscopy. Two simplest models assuming coordination of one or two of… read more here.
Keywords: intermolecular interactions; tricyclic antidepressants; natural humic; interactions natural ... See more keywords
Analysis of tricyclic antidepressants in pharmaceuticals by microemulsion liquid chromatography
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.105659
Abstract: Abstract Basic compounds yield long retention times and broad and asymmetric peaks in reversed-phase liquid chromatography, due to interaction with residual silanols in the columns. The addition of the surfactant sodium dodecyl sulphate in the… read more here.
Keywords: liquid; analysis tricyclic; microemulsion; tricyclic antidepressants ... See more keywords
Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01491-0
Abstract: FKBP51 is an important inhibitor of the glucocorticoid receptor (GR) signaling. High FKBP51 levels are associated to stress-related disorders, which are linked to GR resistance. SUMO conjugation to FKBP51 is necessary for FKBP51’s inhibitory action… read more here.
Keywords: glucocorticoid receptor; sumoylation; activity; tricyclic antidepressants ... See more keywords
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2188147
Abstract: Abstract Carbonic anhydrases (CAs) are important regulators of pH homeostasis and participate in many physiological and pathological processes. CA activators (CAAs) are becoming increasingly important in the biomedical field since enhancing CA activity may have… read more here.
Keywords: tricyclic antidepressants; phenothiazine based; antihistamines phenothiazine; vii ... See more keywords
Tricyclic Antidepressants Found in Pilots Fatally Injured in Civil Aviation Accidents
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.13257
Abstract: Prevalence of tricyclic antidepressants (TCAs) has not been explored in pilots. The National Transportation Safety Board (NTSB) aviation accident and the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) toxicology and medical certification databases were… read more here.
Keywords: pilots fatally; aviation accidents; tricyclic antidepressants; fatally injured ... See more keywords
Tricyclic Antidepressants in Nociceptive and Neuropathic Pain: A Review of Their Analgesic Properties in Combination With Opioids
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pharmacy Technology"
DOI: 10.1177/87551225221139699
Abstract: Objectives: To determine the efficacy and safety of commonly prescribed tricyclic antidepressants (TCAs) as analgesics for nociceptive and neuropathic pain in combination with opioids. Data Sources: A comprehensive literature review was conducted with the assistance… read more here.
Keywords: tricyclic antidepressants; review; nociceptive neuropathic; neuropathic pain ... See more keywords
Effects of tricyclic antidepressants, selective serotonin reuptake inhibitors, and selective serotonin-norepinephrine reuptake inhibitors on the ocular surface.
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos brasileiros de oftalmologia"
DOI: 10.5935/0004-2749.20230068
Abstract: PURPOSE This study aimed to investigate the effects of tricyclic antidepressants, selective serotonin reuptake inhibitors, and selective serotonin noradrenaline reuptake inhibitors on the ocular surface. METHODS The study included 330 eyes of 165 patients using… read more here.
Keywords: tricyclic antidepressants; reuptake inhibitors; selective serotonin; group ... See more keywords