Computational fragment-based design of Wee1 kinase inhibitors with tricyclic core scaffolds
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DOI: 10.1007/s11224-018-1176-3
Abstract: Wee1 is cell cycle protein comprising a kinase domain and is a validated cancer target. We have designed molecules with variable tricyclic core scaffolds [6-6-5] system and extended them based on the chemical space available… read more here.
Keywords: core scaffolds; kinase; wee1 kinase; tricyclic core ... See more keywords
Construction of the [7-5-5] Tricyclic Core of Daphniphyllum Alkaloids via a Cationic Cascade Reaction.
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DOI: 10.1021/acs.orglett.2c04023
Abstract: The [7-5-5] tricyclic core of daphniphyllum alkaloids, containing contiguous stereogenic centers at C14 and C15 and a tetrasubstituted alkene moiety between C9 and C10, was constructed via a cascade reaction that involved an electrocyclic reaction… read more here.
Keywords: tricyclic core; reaction; core daphniphyllum; daphniphyllum alkaloids ... See more keywords
A C–H Activation Approach to the Tricyclic Core of Glionitrin A and B
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DOI: 10.1021/acsomega.2c00810
Abstract: Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and… read more here.
Keywords: tricyclic core; approach; activation; core glionitrin ... See more keywords
An improved synthesis of the [5.6.7]-tricyclic core of cyrneine B and glaucopine C
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DOI: 10.1039/d0qo00758g
Abstract: A new route for the synthesis of the [5.6.7]-tricyclic core structure of cyrneine B and glaucopine C is presented. The key transformations included an efficient Suzuki cross-coupling of the densely substituted cyclopentenyl triflate with cyclic… read more here.
Keywords: cyrneine glaucopine; synthesis tricyclic; tricyclic core; core ... See more keywords