Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents.
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DOI: 10.1016/j.ejmech.2019.05.005
Abstract: Male late-onset hypogonadism (LOH) is reported as one of the most common age-related diseases occurred in middle-aging men. Testosterone replacement therapy (TRT) is currently the main clinical treatment for LOH, however it has obvious side… read more here.
Keywords: late onset; fused tricyclic; methylpyrimidine fused; tricyclic diterpene ... See more keywords