The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
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DOI: 10.1021/acs.jmedchem.6b01496
Abstract: Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation… read more here.
Keywords: tricyclic sulfonamides; lead optimization; glycine receptors; optimization ... See more keywords