Synthesis of tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives linked morpholine moiety as CDK2 inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22074
Abstract: With the aim of developing cyclin-dependent kinase 2 (CDK2) inhibitors with strong antibreast cancer efficacy, new tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives were synthesized. The newly synthesized tri- and tetracyclic derivatives were achieved from the reaction… read more here.
Keywords: cycloheptane derivatives; tricyclic tetracyclic; tetracyclic benzo; benzo cycloheptane ... See more keywords
Rh(III)-Catalyzed Chemodivergent Annulations between Indoles and Iodonium Carbenes: A Rapid Access to Tricyclic and Tetracyclic N-Heterocylces.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01167
Abstract: Herein, we report an acid-controlled highly tunable selectivity of Rh(III)-catalyzed [4 + 2] and [3 + 3] annulations of N-carboxamide indoles with iodonium ylides lead to form synthetically important tricyclic and tetracyclic N-heterocycles. Here, iodonium… read more here.
Keywords: annulations indoles; catalyzed chemodivergent; iii catalyzed; tricyclic tetracyclic ... See more keywords
Catalytic Asymmetric and Divergent Synthesis of Tricyclic and Tetracyclic Spirooxindoles: Controllable Site-Selective Electrophilic Halocyclization of 1,6-Enynes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02202
Abstract: Catalytic asymmetric and divergent assembly of tricyclic and tetracyclic 3,3'-pyrrolidonyl spirooxindoles was developed, involving a one-pot chiral Brønsted base catalyzed asymmetric propargylation for the synthesis of oxindole 1,6-enynes and a subsequent switchable site-selective and highly… read more here.
Keywords: site selective; tricyclic tetracyclic; asymmetric divergent; catalytic asymmetric ... See more keywords