Isobavachalcone suppresses the TRIF‐dependent signaling pathway of Toll‐like receptors
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100404
Abstract: Toll‐like receptors (TLRs) are integral membrane‐bound receptors that are central to innate and adaptive immune responses. They are known to activate a cascade of downstream signals to induce the secretion of inflammatory cytokines, chemokines, and… read more here.
Keywords: dependent signaling; trif dependent; signaling pathways; like receptors ... See more keywords
Anti-inflammatory action of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone (CMEP-NQ) suppresses both the MyD88-dependent and TRIF-dependent pathways of TLR4 signaling in LPS-stimulated RAW264.7 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.04.029
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The roots of Rubia cordifolia L. have been widely used as a traditional herbal medicine in Northeast Asia for treating inflammatory diseases. AIM OF THE STUDY To elucidate the anti-inflammatory mechanism of 2-carbomethoxy-2,3-epoxy-3-… read more here.
Keywords: anti inflammatory; lps; cmep; myd88 dependent ... See more keywords
P748Afterload-induced TRIF-dependent signaling promotes fibrosis but not cardiomyocyte hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0350
Abstract: Pressure overload dependent cardiac remodeling is characterized by a continuous functional loss of cardiomyocytes, cardiomyocyte hypertrophy, cell death and fibrosis. The relevance of the MyD88- and NFκB-independent inflammatory TRIF (TIR-domain-containing adapter protein inducing IFN-β) signaling… read more here.
Keywords: cardiomyocyte hypertrophy; hypertrophy; trif mice; trif dependent ... See more keywords