MLL1 promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by activating the TRIF/NF-κB signaling pathway via H3K4me3 enrichment in the TLR4 promoter region.
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DOI: 10.1016/j.intimp.2020.106220
Abstract: Rheumatoid arthritis (RA) is the most common inflammatory arthritis and is a major cause of disability. Interestingly, the histone methyltransferase mixed-lineage leukemia 1 (MLL1) has been linked to many inflammation-related diseases. Moreover, toll-like receptor 4… read more here.
Keywords: tlr4; trif signaling; mll1; migration invasion ... See more keywords