Trifluoroacetic Acid‐Mediated Cyclization of α‐Mercapto Ketones with Trifluoromethyl N‐Acylhydrazones for the Synthesis of 2‐Trifluoromethylthiazole Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.70213
Abstract: A novel method for synthesizing fully substituted 2‐trifluoromethylthiazoles is reported, achieving yields up to 94% via trifluoroacetic acid (TFA)‐mediated intermolecular cyclization of α‐mercapto ketones with trifluoromethyl N‐acylhydrazones under mild, open‐flask conditions. This reaction involves cleavage… read more here.
Keywords: ketones trifluoromethyl; trifluoromethyl acylhydrazones; cyclization mercapto; mercapto ketones ... See more keywords
Enhanced biobutanol production from corncob via dilute trifluoroacetic acid compared with dilute sulfuric acid pretreatment
Sign Up to like & getrecommendations! Published in 2025 at "Biofuels, Bioproducts and Biorefining"
DOI: 10.1002/bbb.70060
Abstract: Efficient hydrolysis of hemicellulose to fermentable carbohydrates is crucial for producing butanol from lignocellulose. This study investigates hydrothermal pretreatment catalyzed by dilute trifluoroacetic acid (DTFA) to enhance the hydrolysis of hemicellulose in corncob. DTFA pretreatment… read more here.
Keywords: dilute trifluoroacetic; corncob; acid pretreatment; trifluoroacetic acid ... See more keywords
Trifluoroacetic Acid in the Environment: Consensus, Gaps, and Next Steps
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5963
Abstract: There is ongoing debate about the sources, fate, toxicity, and, ultimately, the ecological risk posed by tri fl uoroacetic acid read more here.
Keywords: acid environment; environment consensus; gaps next; trifluoroacetic acid ... See more keywords
Adamantylation of N-aryl and N-arylalkyl acetamides in trifluoroacetic acid
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2873-9
Abstract: Alkylation of N-aryl and N-arylalkyl acetamides with hydroxy adamantane derivatives in trifluoroacetic acid was studied. The differentiating effect of trifluoroacetic acid on the regio-selectivity of adamantylation of o-alkyl-substituted acetanilides was established, leading to energetically more… read more here.
Keywords: trifluoroacetic acid; aryl arylalkyl; adamantylation aryl; acetamides trifluoroacetic ... See more keywords
Synthesis, characterization, and utility of trifluoroacetic acid lanthanide precursors for production of varied phase fluorinated lanthanide nanomaterials
Sign Up to like & getrecommendations! Published in 2017 at "Polyhedron"
DOI: 10.1016/j.poly.2017.04.032
Abstract: Abstract The synthesis of a series of lanthanide trifluoroacetic acid (H-TFA) derivatives which contain only the TFA and its conjugate acid has been developed. From the reaction of Ln(N(SiMe3)2)3 with an excess amount of H-TFA,… read more here.
Keywords: trifluoroacetic acid; tfa; pdf; tfa tfa ... See more keywords
Evaluation of strategies for overcoming trifluoroacetic acid ionization suppression resulted in single-column intact level, middle-up, and bottom-up reversed-phase LC-MS analyses of antibody biopharmaceuticals.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122512
Abstract: A wide range of strategies for efficient chromatography and high MS sensitivity in reversed-phase LC-MS analysis of antibody biopharmaceuticals and their large derivates has been evaluated. They included replacing trifluoroacetic acid with alternative acidifiers, relevancy… read more here.
Keywords: phase; trifluoroacetic acid; column; antibody biopharmaceuticals ... See more keywords
Simple Addition of Glycine in Trifluoroacetic Acid-containing Mobile Phases Enhances the Sensitivity of Electrospray Ionization Mass Spectrometry for Biopharmaceutical Characterization.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01319
Abstract: Trifluoroacetic acid (TFA) is a commonly used mobile phase additive in liquid chromatography-mass spectrometry (LC-MS) based biopharmaceutical characterization to enhance reversed-phase chromatographic performance of peptide separation, however it leads to significant mass spectrometry signal suppression… read more here.
Keywords: mobile phases; characterization; trifluoroacetic acid; mass spectrometry ... See more keywords
Changes in the Local Structure of Nephila clavipes Dragline Silk Model Peptides upon Trifluoroacetic Acid, Low pH, Freeze-Drying, and Hydration Treatments Studied by 13C Solid-State NMR.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01267
Abstract: The conformational analysis of spider dragline silks is difficult because of the amorphous character of the silks. In this article, the fractions of several conformations were determined for three 47-mer peptides, (Glu)4(Ala)6GlyGly12Ala13Gly14GlnGlyGlyTyrGlyGlyLeuGlySerGlnGly25Ala26Gly27-ArgGlyGlyLeuGlyGlyGlnGly35Ala36Gly37(Ala)6(Glu)4, with three underlined… read more here.
Keywords: freeze drying; trifluoroacetic acid; acid low; low freeze ... See more keywords
The Global Threat from the Irreversible Accumulation of Trifluoroacetic Acid (TFA)
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.4c06189
Abstract: Trifluoroacetic acid (TFA) is a persistent and mobile substance that has been increasing in concentration within diverse environmental media, including rain, soils, human serum, plants, plant-based foods, and drinking water. Currently, TFA concentrations are orders… read more here.
Keywords: acid tfa; threat; accumulation; trifluoroacetic acid ... See more keywords
Trifluoroacetic Acid Concentrations in Consumer Foods.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c07390
Abstract: Trifluoroacetic acid (TFA), which is a short chain, persistent perfluoroalkyl acid (PFAA), is ubiquitous due to its numerous sources and environmental persistence. TFA produced in the atmosphere is washed out in wet deposition and acquired… read more here.
Keywords: food; acid concentrations; trifluoroacetic acid; consumer foods ... See more keywords
Trifluoroacetic Acid-Mediated Oxidative Self-Condensation of Acetophenones in the Presence of SeO2: A Serendipitous Approach for the Synthesis of Fused [1,3]Dioxolo[4,5-d][1,3]dioxoles
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c01466
Abstract: A method for the synthesis of fused 1,3-dioxolanes was developed by self-condensation of glyoxal generated in situ by oxidation of acetophenones with SeO2 in the presence of trifluoroacetic acid. Three molecules of the glyoxal generated… read more here.
Keywords: synthesis fused; self condensation; trifluoroacetic acid; presence ... See more keywords