Enantioselective Synthesis of Secondary β-Trifluoromethyl Alcohols via Catalytic Asymmetric Reductive Trifluoroalkylation and Diastereoselective Reduction.
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DOI: 10.1021/jacs.2c01422
Abstract: Fluorinated motifs are frequently encountered in drugs and agrochemicals. Incorporating fluorine-containing motifs in drug candidates for lead optimization in pharmaceutical research and development has emerged as a powerful tool. The construction of molecules that feature… read more here.
Keywords: trifluoroalkylation; enantioselective synthesis; synthesis secondary; reduction ... See more keywords